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Retrospective Cohort Study: Scope for Improvement-Barriers to Post-Polypectomy Surveillance in the Integrated Technologies for Improved Polyp Surveillance Cohort.
Aliment Pharmacol Ther
January 2025
School of Cancer Sciences, College of Medical Veterinary and Life Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Garscube Estate, Glasgow, UK.
Background: Adherence to post-polypectomy surveillance is poor despite evidence that it is associated with lower risk of future colorectal cancer.
Methods: We evaluated 6,210 bowel screening participants between 2009-2016 in NHS Greater Glasgow and Clyde to assess potential barriers to post-polypectomy surveillance.
Results: Increasing deprivation (Scottish Index of Multiple Deprivation quintile 1 vs 5; OR 1.
Spatial datasets of CMIP6 climate change projections for Canada and the United States.
Data Brief
February 2025
Great Lakes Forestry Centre, Natural Resources Canada, 1219 Queen Street East, Sault Ste Marie, Ontario P6A 2E5, Canada.
Geospatial climate change projections are critical for assessing climate change impacts and adaptations across a wide range of disciplines. Here we present monthly-based grids of climate change projections at a 2-km resolution covering Canada and the United States. These data products are based on outputs from the 6th Coupled Model Intercomparison Project (CMIP6) and include projections for 13 General Circulation Models (GCMs), three Shared Socio-economic Pathways (SSP1 2.
View Article and Find Full Text PDFIsolated microhematuria in potential kidney donors: evaluating kidney biopsy findings with dipstick urinalysis and urine microscopy results.
Clin Kidney J
January 2025
Department of Kidney and Pancreas Transplant, Organ Transplant Center of Excellence, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Background: Isolated microhematuria (IMH) can signal hidden glomerular disease, necessitating detailed evaluations for potential kidney donors, including kidney biopsies. The optimal strategy for deciding on kidney biopsies remains unclear. While the British Transplant Society supports dipstick analysis, KDIGO focuses solely on urine microscopy.
View Article and Find Full Text PDFKIF9 Ameliorates Neuropathology and Cognitive Dysfunction by Promoting Macroautophagy in a Mouse Model of Alzheimer's Disease.
Aging Cell
January 2025
Growth, Development, and Mental Health of Children and Adolescence Center, Pediatric Research Institute, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China.
Alzheimer's disease (AD) is a prevalent neurodegenerative disorder affecting the elderly. The imbalance of protein production and degradation processes leads to the accumulation of misfolded and abnormally aggregated amyloid-beta (Aβ) in the extracellular space and forms senile plaques, which constitute one of the most critical pathological hallmarks of AD. KIF9, a member of the kinesin protein superfamily, mediates the anterograde transport of intracellular cargo along microtubules.
View Article and Find Full Text PDFOptokinetic After-Nystagmus: A Marker for Migraine? A Prospective Observational Study.
J Otolaryngol Head Neck Surg
January 2025
Département d'ORL du CHUS, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
Introduction: Vestibular migraine (VM), particularly its chronic variant, poses a diagnostic challenge. Patients suffering from VM may not have the characteristic headaches associated with the dizziness. In these cases, a marker for migraine pathology in general could help appropriately diagnose certain types of dizziness as migrainous despite these patients not meeting current diagnostic criteria for VM.
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