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Rostellularia procumbens (L) Nees. extract attenuates adriamycin-induced nephropathy by maintaining mitochondrial dynamics balance via SIRT1/PGC-1α signaling pathway activation.
J Ethnopharmacol
January 2025
School of Basic Medical Science, Hubei University of Chinese Medicine, Wuhan, 430065, China. Electronic address:
Ethnopharmacological Relevance: Rostellularia procumbens (L) Nees. (R. procumbens) is a classical Chinese herbal medicine that has been used for effective treatment of kidney disease for nearly a thousand years in China.
View Article and Find Full Text PDFFbxo11 maintains mitochondrial function and prevents podocyte injury in adriamycin-induced nephropathy by mediating the ubiquitin degradation of Fosl2.
Exp Cell Res
January 2025
Department of Nephrology, General Hospital of Northern Theater Command, No.83, Wenhua Road, Shenhe District, Shenyang, Liaoning, 110016, China. Electronic address:
Mitochondrial dysfunction is a pivotal factor in the onset of podocyte damage, which is a central component in the pathogenesis of nephrotic syndrome (NS). However, the precise mechanisms underlying the changes in podocyte mitochondria remain elusive. Our study aims to clarify the potential mechanisms involved in the role of F-box protein 11 (Fbxo11) in NS, specifically concentrating on its impact on mitochondrial function.
View Article and Find Full Text PDFProtopanaxadiol synergizes with glucocorticoids to enhance the therapeutic effect in adriamycin-induced nephrotic syndrome.
J Steroid Biochem Mol Biol
January 2025
School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264005, PR China. Electronic address:
To date, glucocorticoids remain the mainstay of treatment of nephrotic syndrome (NS). However, serious side effects and development of drug-resistance following long-term use limit the application of glucocorticoids. Protopanaxadiol (PPD) possesses activity of dissociating transactivation from transrepression by glucocorticoid receptor (GR), which may serve as a potential selective GR modulator.
View Article and Find Full Text PDFSenolytic effect of triterpenoid complex from on adriamycin-induced senescent human hepatocellular carcinoma cells model and .
Front Pharmacol
September 2024
Fujian Provincial Key Laboratory of Pharmacology of Natural Medicine, School of Pharmacy, Fujian Medical University, Fuzhou, China.
Article Synopsis
- A triterpenoid complex (TC) from a famous medicinal mushroom has shown potential as a senolytic agent, selectively eliminating senescent cells in liver cancer (HCC) triggered by chemotherapy.
- The study reveals that TC induces apoptosis through specific cellular pathways and blocks the harmful effects of senescent cells, which normally promote tumor growth.
- Combining TC with chemotherapeutic agents like Adriamycin (ADR) not only reduces tumor growth but also mitigates ADR's side effects, suggesting a promising new approach in cancer treatment.
Paricalcitol prevents MAPK pathway activation and inflammation in adriamycin-induced kidney injury in rats.
J Pathol Transl Med
September 2024
Laboratory of Renal Physiology, Department of Physiology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil.
Background: Activation of the mitogen-activated protein kinase (MAPK) pathway induces uncontrolled cell proliferation in response to inflammatory stimuli. Adriamycin (ADR)-induced nephropathy (ADRN) in rats triggers MAPK activation and pro-inflammatory mechanisms by increasing cytokine secretion, similar to chronic kidney disease (CKD). Activation of the vitamin D receptor (VDR) plays a crucial role in suppressing the expression of inflammatory markers in the kidney and may contribute to reducing cellular proliferation.
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