The evolution of serum and hypothalamic concentrations of endogenous testosterone was measured in newborn male and female Rats, from 0 up to 6 hrs. after birth. The serum testosterone surge observed in males between 0 and 2 hrs. was not found in the females. During this period, the hypothalamic concentration of testosterone increased in males but decreased in the females.
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J Ethnopharmacol
January 2025
Center for Sustainable Development, College of Arts and Sciences, Qatar University, Doha 2713, Qatar. Electronic address:
Ethnopharmacological Relevance: Benign prostatic hyperplasia (BPH) is one of the most prominent diseases of the aged men urinary system. It is associated with cellular proliferation, hormonal imbalance, oxidative stress, inflammation and apoptosis. Traditionally, Thymelaea hirsuta (L.
View Article and Find Full Text PDFSex Med
December 2024
Visiting staff, Division of Urology, Department of Surgery, Yuan's General Hospital, Kaohsiung City 802793, Taiwan, Republic of China.
Background: Both serum testosterone (T) levels and erectile dysfunction (ED) are associated with systemic diseases in men and ED is the most common presenting symptom of hypogonadism.
Aim: To evaluate the association of serum total testosterone (TT) levels with cardiometabolic diseases in men with ED.
Methods: Serum endogenous TT levels were determined to evaluate their associations with cardiometabolic diseases in men with ED in outpatient clinics.
J Clin Endocrinol Metab
January 2025
3Department of Metabolism, Digestion and Reproduction, Imperial College London.
Pubertal disorders in the form of delayed puberty (DP) or precocious puberty (PP) can cause considerable anxiety to both children and parents. Since the clinical and biochemical signatures of self-limiting and permanent conditions overlap considerably, it can be hard to determine whether to offer them reassurance or intervention. Researchers have thus long been searching for a robust test to indicate that the process of endogenous puberty is underway and is likely to proceed to completion.
View Article and Find Full Text PDFDrug Test Anal
January 2025
Department of Pharmacology, Faculty of Science, Mahidol University, Bangkok, Thailand.
Triptorelin, a synthetic gonadotrophin-releasing hormone (GnRH), is mainly used in the clinical treatment of prostate cancer. The mechanism initially stimulates luteinizing hormone (LH) and testosterone secretion followed by suppression, resulting in a reduction in cancer progression. However, GnRHs are prohibited in doping control because of the indirect surge of LH and testosterone.
View Article and Find Full Text PDFJ Sex Med
January 2025
Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui Province, China.
Background: There have been many studies of the association between testosterone and cardiovascular disease (CVD). However, limited research has examined the association between testosterone and Life's Essential 8 (LE8), a recently updated algorithm for assessing cardiovascular health (CVH).
Objectives: This study aims to investigate the association between serum total testosterone (TT) levels and LE8 scores-where higher LE8 scores indicate better CVH-among adult males in the United States.
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