Transversal overloading /3.5 and 6 un/ distinctly altered penetration of 14C-nicotinate and 35S-lipoate into cells and mitochondria. Increased secretion of proteins from cells, mitochondria and lysosomes was observed under these experimental conditions, especially in presence of Triton X-100 and in hypotonic media. Within the first 30 sec of overloading an increase in lipid peroxidation was found. Pretreatment with vitamin E decreased the effect of overloading on lipid peroxidation and on the membrane permeability.
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