Research work has been carried out with the aim of obtaining hyperimmune antitoxic plasma against Pseudomonas aeruginosa. Hyperimmune plasma active against P. aeruginosa toxin has been obtained from donors immunized with P. aeruginosa toxoid. The preparation is highly specific and active, which is revealed by in vivo and in vitro tests. The clinical study of the preparation indicates its high efficacy in the treatment of diseases caused by different P. aeruginosa serotypes.
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[Comparative efficacy of homologous and heterologous biologicals against diphtheria].
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Materials And Methods: Homologous hyperimmune sera were obtained through immunization of rabbits and guinea-pigs with diphtheria toxoid according to schedule. Immune rabbit sera contained 70 - 100 IU/mL of antitoxin antibodies and guinea-pig sera contained 60 - 80 IU/mL.
Development of complications during diphtheria depends to a large extent on toxin-neutralizing antibodies level in the patient's blood. Active immunization of people with diphtheria anatoxin is widely used for diphtheria prevention and passive immunization with hyperimmune antitoxic horse serum is used for diphtheria treatment. A traditional component of anti-diphtheria vaccines--diphtheria anatoxin has a number of serious disadvantages, which are mainly associated with complicated procedure of its production.
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