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Comparison of two modified methods of intrathecal catheterization in rats.

Exp Anim

April 2020

Department of Spine Surgery, The First Affiliated Hospital, Sun Yat-sen University, No. 58, Zhong Shan Er Lu, Guangzhou 510080, Guangdong, China.

The study designed to compare two different methods of intrathecal catheterization in rats and to develop a simple and safe drug administration in cervical spinal canal of rats. The subarachnoid catheterization was performed via either atlanto-occipital membrane or laminectomy at L3-4 in rats. Body weight, Basso, Beattie, and Bresnahan (BBB) locomotion rating scores and forelimb locomotor rating scale (FLS) were measured on pre-operative day 1 and postoperative day 1, 7, 14, respectively.

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