The ultrastructure of the pancreatic islets and insulin content in the beta-cells, revealed by histochemical technique after glybenclamide loading, was investigated in rats. Glybenclamide administration led to the loss in beta-cells of a greater portion of their hormone depot. Ultrastructurally, a significant development in all the organellae of the protein synthesizing apparatus was demonstrated, this testifying to a sharp rise of the hormone production. At the same time insulin released from the cells was accelerated, although no final and complete formation of beta-granules occurred, alpha-insulocytes appeared to be intact.
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