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http://dx.doi.org/10.1016/0013-9351(80)90152-8 | DOI Listing |
J Toxicol Sci
January 2025
Safety Science Research Laboratories, Kao Corporation.
The human Cell Line Activation Test (h-CLAT) is an in vitro skin sensitization assay adopted by the OECD as Test Guideline 442E. In the h-CLAT, 2,4-dinitrochlorobenzene (DNCB) is used as a positive control; however, DNCB is considered a poisonous substance under the Poisonous and Deleterious Substances Control Act in Japan since 2014 because of its high acute toxicity. Strict control, handling, and storage are required when using DNCB, which is a burden to the users.
View Article and Find Full Text PDFMolecules
November 2024
Department of Toxicology, Dairy Technology and Food Storage, Faculty of Food Sciences and Fisheries, West Pomeranian University of Technology, 70-310 Szczecin, Poland.
Hexachlorobenzene (HCB) is a persistent organic pollutant (POP) commonly detected in milk and dairy products. These compounds pose a serious threat to the health of consumers due to their considerable bioaccumulation potential, high stability, and toxicity. (2) Methods: The study evaluated the potential of and probiotic cultures to reduce HCB residues in fermented goat milk beverages during 21-day refrigerated storage.
View Article and Find Full Text PDFEnviron Pollut
February 2025
Laboratoire des Sciences du Climat et de l'Environnement (LSCE-IPSL), Université Paris-Saclay, Unité Mixte de Recherche 8212 (CEA/CNRS/UVSQ), Orme des Merisiers, 91191 Gif-Sur-Yvette, France.
Clin Exp Pediatr
November 2024
Department of Pediatrics, Inje University Sanggye Paik Hospital, Seoul, Korea.
Int J Biol Macromol
December 2024
Department of Pharmacy, Air Force Medical Center, PLA, Air Force Medical University, Beijing 100142, China. Electronic address:
Nanoformulation have been widely used in skin and transdermal drug delivery. However, the differences in integral nanoparticles absorption in healthy and diseased skin have not yet fully analyzed. The present study attempted to explore the percutaneous absorption of drugs via lesional skin by using atopic dermatitis (AD) as a model, dinitrochlorobenzene (DNCB) induced AD-like skin.
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