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[Malignant transformation of human bronchial epithelial cells induced by benzo(a)pyrene metabolite dihydroxyepoxy benzo pyrene].
Wei Sheng Yan Jiu
May 2001
Institute for Chemical Carcinogenesis, Guangzhou Medical College, Guangzhou 510182, China.
The malignant transformation of human bronchial epithelial cell 16HBE induced by benzo (a) pyrene metabolite--dihydroxyepoxy benzo pyrene (BPDE) was studied. 16HBE cells were treated several times with BPDE at different concentrations in vitro. The identification on the malignancy of transformed 16HBE cells was investigated.
View Article and Find Full Text PDFCytochrome P450 mediated reactions studied in genetically engineered V79 Chinese hamster cells.
Pharmacogenetics
November 1995
Institute for Toxicology and Environmental Hygiene, Technical University of Munich, Germany.
V79 Chinese hamster cells genetically engineered for stable expression of rat and human CYP have been shown to serve as analytical tools for studying metabolism related problems in toxicology and pharmacology. Here, the application of rat and human CYP1A1 and CYP1A2 is demonstrated for comparative studies on the oxidation of polycyclic aromatic hydrocarbons, such as phenanthrene, benz[a]anthracene, and benzo[a]pyrene. Live cells were cultivated for 2 days in the presence of these chemicals.
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