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Melatonin antagonizes bone loss induced by mechanical unloading via IGF2BP1-dependent mA regulation.
Cell Mol Life Sci
January 2025
The Key Laboratory of Aerospace Medicine, Ministry of Education, Air Force Medical University, Xi'an, 710032, Shaanxi, China.
Disuse bone loss is prone to occur in individuals who lack mechanical stimulation due to prolonged spaceflight or extended bed rest, rendering them susceptible to fractures and placing an enormous burden on social care; nevertheless, the underlying molecular mechanisms of bone loss caused by mechanical unloading have not been fully elucidated. Numerous studies have focused on the epigenetic regulation of disuse bone loss; yet limited research has been conducted on the impact of RNA modification bone formation in response to mechanical unloading conditions. In this study, we discovered that mA reader IGF2BP1 was downregulated in both osteoblasts treated with 2D clinostat and bone tissue in HLU mice.
View Article and Find Full Text PDFEvolution of treatment of fragility fractures of the pelvic ring. An update.
Injury
January 2025
Professor of Orthopedics - Section Head Trauma & Orthopaedic Surgery, School of Medicine University of Leeds, UK.
The term "fragility fractures of the pelvis" refers to the disruptions of the pelvic ring that are caused by low energy injuries (such as low-level falls or falls from the standing position) in the elderly population (age over 65 years) in the absence of metastatic bone disease. These fractures are increasing in numbers, due to the aging population, particularly in the developed countries, causing significant morbidity and mortality [1]. Although some fracture patterns are stable enough requiring only conservative treatment, other fracture types can cause significant pelvic instability, demanding a more insistent management protocol.
View Article and Find Full Text PDFForeign Body Entrapment on the Bearing Surface in Total Hip Arthroplasty: A Report of Three Cases.
Cureus
December 2024
Department of Orthopedic Surgery, Japanese Red Cross Shizuoka Hospital, Shizuoka, JPN.
Total hip arthroplasty (THA) is a highly effective surgical intervention for end-stage hip joint disorders. While common complications such as infection, dislocation, and prosthetic loosening are well-documented, rarer complications remain underreported. One such complication is foreign body interposition on the bearing surface, which can compromise joint mechanics and adversely affect outcomes.
View Article and Find Full Text PDFTreatment of Femoral Neck Fractures in Adults With Improved Biplane Double-Supported Screw Fixation and Femoral Neck System: Complications and Surgical Techniques.
Orthop Surg
January 2025
Division of Orthopaedics and Traumatology, Department of Orthopaedics, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Objectives: Treating femoral neck fractures remains a significant challenge for orthopedic surgeons and imposes a substantial economic burden on developing regions. Current novel internal fixation methods demonstrate excellent biomechanical performance. However, these new internal fixation methods are still associated with various complications.
View Article and Find Full Text PDFPrognostic Value of the CURL Classification System for Proximal Ulna Fracture Dislocations of the Elbow.
J Shoulder Elbow Surg
January 2025
Department of Orthopaedic Surgery, Royal County Sussex Hospital, University Hospitals Sussex NHS Foundation Trust, Brighton, UK; Brighton and Sussex Medical School, Brighton, UK. Electronic address:
Background: Proximal ulna fracture-dislocations comprise a wide spectrum of injury. The Coronoid, proximal Ulna, Radius and Ligaments (CURL) classification is a simple framework designed to aid surgical decision making by focusing attention on the key components of the injury and their relative severity. It has been demonstrated to have a high inter and intra-observer reliability.
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