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Exploring apolipoprotein C-III: pathophysiological and pharmacological relevance.
Cardiovasc Res
February 2024
Center for the Study of Dyslipidaemias, IRCCS MultiMedica, Sesto S. Giovanni, 20099 Milan, Italy.
Article Synopsis
- The use of drugs to lower LDL cholesterol (LDL-C) has significantly decreased the risk of heart disease, but some cardiovascular risk remains.
- Elevated triglycerides (TGs) and TG-rich lipoproteins are linked to increased cardiovascular risk, highlighting the need to address these factors.
- New treatments targeting apolipoprotein C-III (apoC-III), which plays a crucial role in TG metabolism, show promise in further reducing triglyceride levels and associated heart disease risk.
Herbal medicine formula Huazhuo Tiaozhi granule ameliorates dyslipidaemia via regulating histone lactylation and miR-155-5p biogenesis.
Clin Epigenetics
November 2023
Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100032, China.
Background: Huazhuo Tiaozhi granule (HTG) is a herbal medicine formula widely used in clinical practice for hypolipidaemic effects. However, the molecular mechanisms underlying dyslipidaemia treatment have not been well elucidated.
Results: A significant reduction in the levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) was observed in the serum of patients with dyslipidaemia after HTG treatment, without disruption in the levels of aspartate transaminase (AST), alanine transaminase (ALT), urea nitrogen (BUN), and creatinine (Cr).
Rhamnogalacturonan-I enriched pectin from steamed ginseng ameliorates lipid metabolism in type 2 diabetic rats via gut microbiota and AMPK pathway.
J Ethnopharmacol
January 2023
Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, 130117, China. Electronic address:
Ethnopharmacological Relevance: Panax ginseng C. A. Meyer (Ginseng) has traditionally been used to treat diabetes.
View Article and Find Full Text PDFPineapple fruit improves vascular endothelial dysfunction, hepatic steatosis, and cholesterol metabolism in rats fed a high-cholesterol diet.
Food Funct
October 2022
Department of Physiology, Faculty of Medical Sciences, Naresuan University, Phitsanulok, 65000, Thailand.
Hypercholesterolaemia is a significant risk factor for developing vascular disease and fatty liver. Pineapple (), a tropical fruit widely cultivated in Asia, is reported to exhibit antioxidant and cholesterol-lowering activity; however, the potential hypolipidaemic mechanisms of pineapple fruit remain unknown. Therefore, we aimed to identify the anti-hypercholesterolaemic mechanism of pineapple fruit and to study the effect of pineapple fruit intake on hypercholesterolaemia-induced vascular dysfunction and liver steatosis in a high-cholesterol diet (HCD)-fed rats.
View Article and Find Full Text PDFDiet containing dehulled adlay ameliorates hepatic steatosis, inflammation and insulin resistance in rats with non-alcoholic fatty liver disease.
Br J Nutr
August 2022
Department of Nutritional Science, Fu Jen Catholic University. No.510, Zhongzheng Rd., Xinzhuang Dist., New Taipei City24205, Taiwan.
Dietary modification plays a vital role in the treatment of non-alcoholic liver diseases. We investigated the effects of the consumption of a different amount of dehulled adlay, which has hypolipidaemic and anti-inflammatory properties, on non-alcoholic fatty liver disease (NAFLD). We fed rats a high-fat-high-fructose liquid diet for 16 weeks to induce NAFLD.
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