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Single-cell transcriptome profiles and E-64 inhibitor data reveal the essential role of cysteine proteases in the ontogeny of Ichthyophthirius multifiliis.
Fish Shellfish Immunol
November 2024
Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, 430072, Wuhan, China. Electronic address:
Article Synopsis
- Ichthyophthiriasis, or white spot disease, poses serious economic risks for fish farmers, making it essential to understand its pathogenic mechanisms for effective prevention.
- This study used single-cell RNA sequencing to analyze the stages of the parasite Ichthyophthirius multifiliis, identifying key proteins involved in its invasion, particularly at the theront stage.
- The research highlighted the role of cysteine proteases and demonstrated that the inhibitor E-64 effectively kills the theront and protomont stages of the parasite, paving the way for future strategies against Ichthyophthiriasis.
Immunological effects of DNA vaccination and interleukin utilization as an adjuvant in Astyanax lacustris immunized against Ichthyophthirius multifiliis.
J Fish Dis
September 2024
Laboratory of Immunology of Parasites, Department of Veterinary Medicine, Faculty of Animal Science and Food Engineering (FZEA), University of São Paulo (USP), av. Duque de Caxias Norte, São Paulo City, São Paulo, Brazil.
The increasing significance of the aquaculture sector and commercially valuable species underscores the need to develop alternatives for controlling diseases such as Ichthyophthirius multifiliis-induced ichthyophthiriasis. This ciliated protozoan parasite threatens nearly all freshwater fish species, causing substantial losses in the fishery industry. Despite this, effective large-scale treatments are lacking, emphasizing the necessity of adopting preventive strategies.
View Article and Find Full Text PDFWhite spots amidst the gold: ultrastructural and histological aspects of the chronic inflammatory response of goldfish with ichthyophthiriasis.
J Comp Pathol
May 2024
Programa de Pós Graduação em Patologia Ambiental e Experimental, Universidade Paulista - Unip, Rua Doutor Bacelar 902, São Paulo, Brazil.
Ichthyophthirius multifiliis, the causative agent of white spot disease, is a ciliated protozoan parasite that infects freshwater fish and induces high mortality. Outbreaks occur both in natural and production sites. The aim of the present study was to describe the lesions caused by chronic infection by I.
View Article and Find Full Text PDFSilencing of heat shock protein 90 (hsp90): Effect on development and infectivity of Ichthyophthirius multifiliis.
BMC Vet Res
March 2023
Zoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia.
Background: Recently, an increasing number of ichthyophthiriasis outbreaks has been reported, leading to high economic losses in fisheries and aquaculture. Although several strategies, including chemotherapeutics and immunoprophylaxis, have been implemented to control the parasite, no effective method is available. Hence, it is crucial to discover novel drug targets and vaccine candidates against Ichthyophthirius multifiliis.
View Article and Find Full Text PDFComparison of droplet digital PCR and real-time quantitative PCR for quantitative detection of the parasitic ciliate Ichthyophthirius multifiliis in the water environment.
J Fish Dis
April 2023
State Key Laboratory of Freshwater Ecology and Biotechnology and Key Laboratory of Aquaculture Disease Control, Ministry of Agriculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.
Ichthyophthiriasis, caused by the parasitic ciliate Ichthyophthirius multifiliis (Ich), is considered one of the most harmful diseases affecting freshwater fish globally. It can cause mass mortalities of fish in intensive farming systems. In such systems, it is thus necessary to detect and quantify the number of Ich in the water so that control measures can be implemented before Ichthyophthiriasis breaks out.
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