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ECG Patterns of Occlusion Myocardial Infarction: A Narrative Review.
Ann Emerg Med
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Department of Emergency Medicine, University of Minnesota, Minneapolis, MN; Department of Emergency Medicine, Hennepin Healthcare, Minneapolis, MN.
The traditional management of acute coronary syndrome has relied on the identification of ST-segment elevation myocardial infarction (STEMI) as a proxy of acute coronary occlusion. This conflation of STEMI with acute coronary occlusion has historically overshadowed non-ST-segment elevation myocardial infarction (NSTEMI), despite evidence suggesting 25% to 34% of NSTEMI cases may also include acute coronary occlusion. Current limitations in the STEMI/NSTEMI binary framework underscore the need for a revised approach to chest pain and acute coronary syndrome management.
View Article and Find Full Text PDFThe evolution of the Amber additive protein force field: History, current status, and future.
J Chem Phys
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Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, Shanghai Frontiers Science Center of Molecule Intelligent Syntheses, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China.
Molecular dynamics simulations are pivotal in elucidating the intricate properties of biological molecules. Nonetheless, the reliability of their outcomes hinges on the precision of the molecular force field utilized. In this perspective, we present a comprehensive review of the developmental trajectory of the Amber additive protein force field, delving into researchers' persistent quest for higher precision force fields and the prevailing challenges.
View Article and Find Full Text PDFDevelopment of autonomic innervation at the venous pole of the heart: bridging the gap from mice to human.
J Transl Med
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Department of Anatomy & Embryology, Leiden University Medical Center, P.O. Box 9600, Postal Zone: S-1-P, 2300 RC, Leiden, The Netherlands.
Background: Prenatal development of autonomic innervation of sinus venosus-related structures might be related to atrial arrhythmias later in life. Most of the pioneering studies providing embryological background are conducted in animal models. To date, a detailed comparison with the human cardiac autonomic nervous system (cANS) is lacking.
View Article and Find Full Text PDFMedical knowledge and traditional healing practices of the Bororo: reports from an expedition to the interior of Mato Grosso, Brazil, 1911.
Hist Cienc Saude Manguinhos
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Docente, Universidade Estadual de Goiás. Anápolis - GO - Brasil.
This text analyzes the medical reports of doctor Murillo de Campos on an expedition by the Rondon Commission to the Brazilian state of Mato Grosso in 1911. Originally published as a scientific article, the report begins by detailing the nosological profile in the places visited and the customs of the inhabitants. It then presents a detailed fieldwork report into the healing practices of the Bororo indigenous people in eastern Mato Grosso.
View Article and Find Full Text PDFAn ensemble deep learning framework for energy demand forecasting using genetic algorithm-based feature selection.
PLoS One
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Department of Information Systems and Cybersecurity, University of Bisha, Bisha, KSA.
Accurate energy demand forecasting is critical for efficient energy management and planning. Recent advancements in computing power and the availability of large datasets have fueled the development of machine learning models. However, selecting the most appropriate features to enhance prediction accuracy and robustness remains a key challenge.
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