Hydroxyurea is a well known enzyme urease inhibitor. Bacteria strains producers of enzyme urease can be the cause of struvite calculosis. Clinical studies have shown that treatment with hydroxyurea can produce acid urine in patients suffering from struvite calculosis. In this work antiurease and antibacterial activity of hydroxyurea was valued in vitro against Proteus mirabilis strains. Our results seem not to agree with the ones obtained in vivo.
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