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Temporal trends in management strategies and clinical outcomes of venous thromboembolism in Japan from 2017 to 2023.
J Cardiol
March 2025
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Background: Venous thromboembolism (VTE) is a major health problem worldwide. There are scarce data on the recent temporal trends of patients with VTE after the widespread use of direct oral anticoagulants (DOACs).
Methods And Results: In a Japanese nationwide hospital administrative database, we identified 20,217 patients with VTE from 2017 to 2023, and evaluated their temporal trends in management strategies and clinical outcomes.
Multidisciplinary assessment of the impact of assisted reproductive techniques on pregnancy and long-term outcomes of mother and child: Foundation of the LE-REP (Leipzig Reproductive Health) Center.
J Reprod Immunol
March 2025
Institute Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Medical Faculty, Leipzig University, Leipzig, Germany; Leipzig Reproductive Health Research Center (LE-REP), Leipzig University, Leipzig, Germany. Electronic address:
About 8-10 % of all people of reproductive age are unable to conceive children. In recent years, an increased number of consultations for fertility treatments has been observed with a continuing positive trend. It is known that infertility itself and assisted reproductive technologies (ARTs) are frequently associated with recurrent miscarriages, pregnancy complications or psychosocial problems.
View Article and Find Full Text PDFAssessing the Impact of Lymphedema Therapy Referral on Breast Cancer Survivors' Lymphedema Knowledge: A Cross-Sectional Survey.
BMC Womens Health
March 2025
Immigrant Health and Cancer Disparities Service, Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Background: Lymphedema is a common problem that adversely impacts quality of life in breast cancer survivors. Although lymphedema risk is modifiable through behavior change, there is no standardized approach to educate survivors about risk-lowering strategies. Furthermore, misconceptions about lymphedema risk factors and risk-lowering strategies are common.
View Article and Find Full Text PDFRAC1 promotes the occurrence and development of tongue squamous cell carcinoma by regulating RAC1/PAK1/LIMK1 signaling pathway.
Sci Rep
March 2025
Department of Oral and Maxillofacial Surgery, The Affiliated Hospital of Qingdao University, 16 Jiangsu Road, Qingdao, 266000, Shandong Province, China.
Tongue squamous cell carcinoma (TSCC) remains an unsolved medical problem due to its poor local recurrence rate and prognosis. The purpose of this study was to investigate the expression characteristics of RAC-related C3 botulinum toxin substrate 1(RAC1) in TSCCS and its role in tumor invasion and metastasis. In this study, immunohistochemical staining was used to detect RAC1 expression in 150 tongue cancer specimens.
View Article and Find Full Text PDFBest practice offloading treatments for diabetic foot ulcer healing, remission, and better plans for the healing-remission transition.
Semin Vasc Surg
March 2025
Australian Centre for Health Services Innovation & Centre for Healthcare Transformation, School of Public Health and Social Work, Queensland University of Technology, Brisbane, Australia; Department of Rehabilitation Medicine, Amsterdam Movement Sciences,Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Diabetes-related foot disease is arguably the world's least known major health problem and causes a disease burden larger than most well-known diseases, such as stroke and breast cancer. This burden is driven by people developing more severe stages of foot disease, such as foot ulcers and infections, and with that worsening quality of life. To reduce this burden, we need treatments that prevent more severe stages of foot disease and improve quality of life.
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