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Hiding in Plain Sight: An Atypical Presentation of the Uncommon Merkel Cell Carcinoma.
Cureus
March 2024
Dermatology, Palm Beach Dermatology Group, Delray Beach, USA.
Merkel cell carcinoma (MCC) is a cutaneous neoplasm that is challenging to diagnose secondary to its rarity. We report a case involving a 76-year-old Caucasian female with a seemingly benign skin nodule on her right forearm. Histopathological analysis revealed characteristics of MCC, including uniform round cells with minimal cytoplasm and fine granular chromatin.
View Article and Find Full Text PDFMolecular genetics of APUDomas.
Semin Surg Oncol
December 1993
Department of Surgery, University of Michigan Medical Center, Ann Arbor 48109-0331.
It is tempting to speculate that genetic studies of the human APUDomas, particularly those of a hereditary nature, may ultimately provide valuable clues to the molecular basis of malignant transformation in cells of all types, uncover the mechanisms responsible for tumor progression, and perhaps decipher the signals important in the differentiation of normal neural crest-derived tissue. Generally, several strategies have been used in the genetic analysis of these tumors with success. These include (1) cytogenetic examination of recurring chromosomal abnormalities in hopes of pinpointing critical neighboring growth regulatory sequences important in tumor evolution, (2) identification of dominant acting oncogenes in tumor cells, (3) search for recessive inactivated suppressor genes that may regulate cell growth by analyzing tumors for loss of heterozygosity (LOH), and (4) genetic linkage studies of kindreds affected with familial APUDomas to identify and subsequently characterize the predisposition gene using a positional or functional cloning approach.
View Article and Find Full Text PDF[Cutaneous neuroendocrine carcinoma].
Ann Dermatol Venereol
May 1989
Service de Dermatologie, Hôpital Pasteur, Nice.
Two nearly identical cases with about 100 multicentric disseminated neuroendocrine carcinomas of the skin are presented. In the Merkel cell tumors a for epithelial cells specific antigen (MAM-6) was found by immunohistochemical methods. Only in one patient generalized metastases arose after a four year course of the disease.
View Article and Find Full Text PDFA neuroendocrine carcinoma of the skin was diagnosed in one male and four female patients. Their case histories were short (five months on the average). In two patients, we found metastases of the regional lymph nodes already at the first physical examination; another patient died of distant metastases after 15 months.
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