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Association of Obesity and Skeletal Muscle with Postoperative Survival in Non-Small Cell Lung Cancer.
Radiology
January 2025
From the Department of Radiology (J.H.L.) and Department of Thoracic and Cardiovascular Surgery (J.L., Y.J.J., S.Y.P., J.H.C., Y.S.C., J.K., Y.M.S., H.K.K.), Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea; Department of Clinical Research Design and Evaluation, SAIHST, Sungkyunkwan University, 115 Irwon-ro, Gangnam-gu, Seoul 06355, Korea (D.K., J.L., S.Y.P., S.K., J.C.); Center for Clinical Epidemiology, Sungkyunkwan University, Samsung Medical Center, Seoul, Korea (D.K., J.C.); Patient-Centered Outcomes Research Institute, Samsung Medical Center, Seoul, Korea (J.L., Y.M.S., S.K., H.K.K., J.C.); and Department of Epidemiology and Medicine, Welch Center for Prevention, Epidemiology, and Clinical Research, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Md (J.C.).
Background A comprehensive assessment of skeletal muscle health is crucial to understanding the association between improved clinical outcomes and obesity as defined by body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) in lung cancer, but limited studies have been conducted on this topic. Purpose To investigate the association between BMI-defined obesity and survival in patients with non-small cell lung cancer who underwent curative resection, with a specific focus on the status of skeletal muscle assessed at CT. Materials and Methods This retrospective study investigated Korean patients with non-small cell lung cancer who underwent curative resection between January 2008 and December 2019.
View Article and Find Full Text PDFMedial orbitofrontal cortex structure, function, and cognition associates with weight loss for laparoscopic sleeve gastrectomy.
Obesity (Silver Spring)
February 2025
Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Objective: The objective of this study was to investigate underlying mechanisms of long-term effective weight loss after laparoscopic sleeve gastrectomy (LSG) and effects on the medial orbitofrontal cortex (mOFC) and cognition.
Methods: A total of 18 individuals with obesity (BMI ≥ 30 kg/m) underwent LSG. Clinical data, cognitive scores, and brain magnetic resonance imaging scans were evaluated before LSG and 12 months after LSG.
Trajectories of general and central obesity beyond middle age in relation to late-life cognitive decline and dementia.
Obesity (Silver Spring)
February 2025
Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Objective: The objective was to evaluate the longitudinal patterns of central and general obesity, identify their genetic and behavioral risk determinants, and investigate the association of distinct obesity trajectories beyond middle age with subsequent cognitive decline and the risk of developing dementia in late life.
Methods: Using a nationally representative, longitudinal, community-based cohort, we examined trajectory patterns of obesity over a 14-year span beyond middle age employing latent mixture modeling. We then evaluated their relationship with subsequent cognitive decline through linear mixed models and with the risk of developing dementia using Cox models, adjusting for confounding variables.
Trends and Factors Associated With Central Obesity in Schoolchildren in Florianópolis, Santa Catarina, Brazil: Cross Sectional Panel Study From 2002 to 2019.
Am J Hum Biol
January 2025
Federal University of Santa Catarina, Posgraduate Program in Nutrition, Federal University of Santa Catarina, Florianópolis, SC, Brazil.
Objective: This study aimed to assess the trend and factors associated with central obesity in four cross-sectional panels in schoolchildren aged 7-14 years between 2002 and 2019.
Methods: Waist circumference data were used to assess central obesity, and independent variables were gender, age, school shift (morning and afternoon), commuting to school method, mother's schooling, and family income. The chi-square test was used to assess the association between outcome and independent variables, and binary logistic regression was used to assess the predictors of central obesity and the effect size by odds ratio.
Childhood body size, adulthood adiposity, underlying mechanisms, and risk of incident hypertension: a prospective cohort study of 180,527 participants.
BMC Med
January 2025
Department of Epidemiology/Department of Maternal, Child and Adolescent Health, School of Public Health, Qilu Hospital, Shandong University, Jinan, Shandong, China.
Background: Mechanisms underlying the association of life-course adiposity with incident hypertension in adulthood have not been comprehensively investigated. In this study, we aimed to investigate the potential biochemical and metabolomic mechanisms underlying the association between adiposity and incident hypertension.
Methods: A total of 180,527 participants from the UK Biobank aged 37 to 73 years were included.
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