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Impact of Recent Translational and Therapeutic Developments on Clinical Course of BCR::ABL1-Positive and -Negative Myeloproliferative Neoplasms.
Hematol Oncol
January 2025
University of California Irvine, Irvine, California, USA.
Despite the study of BCR::ABL1-positive and -negative myeloproliferative neoplasms (MPNs) providing seminal insights into cancer biology, tumor evolution and precision oncology over the past half century, significant challenges remain. MPNs are clonal hematopoietic stem cell-derived neoplasms with heterogenous clinical phenotypes and a clonal architecture which impacts the often-complex underlying genetics and microenvironment. The major driving molecular abnormalities have been well characterized, but debate on their role as disease-initiating molecular lesions continues.
View Article and Find Full Text PDFEfficacy and Safety of Dupilumab Maintained in Adults ≥ 60 Years of Age with Moderate-to-Severe Atopic Dermatitis: Analysis of Pooled Data from Four Randomized Clinical Trials.
Am J Clin Dermatol
May 2023
Regeneron Pharmaceuticals Inc., Tarrytown, NY, USA.
Background: Adults aged ≥ 60 years are often underrepresented in atopic dermatitis (AD) clinical trials; age-related comorbidities may impact treatment efficacy and safety.
Objective: The aim was to report dupilumab efficacy and safety in patients aged ≥ 60 years with moderate-to-severe AD.
Methods: Data were pooled from four randomized, placebo-controlled dupilumab trials of patients with moderate-to-severe AD (LIBERTY AD SOLO 1 and 2, LIBERTY AD CAFÉ, and LIBERTY AD CHRONOS) and stratified by age (< 60 [N = 2261] and ≥ 60 [N = 183] years).
Standing on the Shoulders of a Giant: Remembrances of Jack Michael, Part 1.
Anal Verbal Behav
June 2021
California State University, Los Angeles, CA USA.
In 1959, Jack Michael and his PhD student Ted Ayllon published "The Psychiatric Nurse as a Behavioral Engineer" (Ayllon & Michael, 1959). That study was Ayllon's doctoral dissertation and was the first empirical demonstration of how the principles of behavior (e.g.
View Article and Find Full Text PDFThe 2020 Nobel Prize for Medicine or Physiology for the Discovery of Hepatitis C Virus: A Triumph of Curiosity and Persistence.
Hepatology
November 2021
Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA.
Article Synopsis
- - The 2020 Nobel Prize in Medicine was awarded to Drs. Harvey Alter, Michael Houghton, and Charles Rice for their groundbreaking work on the hepatitis C virus, leading to lifesaving therapies.
- - The tribute discusses the historical significance of the laureates' discoveries and includes insights from a forum held by the American Association for the Study of Liver Diseases, where the laureates shared advice for emerging scientists.
- - Colleagues and peers in the research community also contribute personal reflections and stories about their experiences working with the Nobel laureates.
Establishing a Nursing Honor Guard.
Nephrol Nurs J
October 2019
Retired Renal and Emergency Room Nurse Administrator, CVPH Medical Center, Plattsburgh, NY.
A group of local nephrology nurses implemented a program to recognize deceased colleagues who have dedicated their professional lives to nursing, similar to existing military and police programs. At the family's request, an honor guard pays tribute to any local retired or active nurse at the time of his or her death. This is an opportunity to pay respect to our peers for their compassion and devotion to caring for the sick.
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