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Outcome measures in muscular dystrophy rehabilitation: an ICF content comparison approach to the most commonly used MD scales.
J Rehabil Med
January 2025
WHOFIC Academic Collaborating Center- Univesitat de Barcelona, Barcelona, Spain; August Pi i Sunyer Biomedical Research Institute (IDIBAPS) University of Barcelona, Barcelona, Spain; Physical and Rehabilitation Department, Hospital Clinic, ICEMEQ, Barcelona, Spain; Clinical and Experimental Respiratory Immunoallergy (IRCE), Clinic Foundation for Biomedical Research, Barcelona, Spain.
Introduction: Functioning is the reason to be of rehabilitation as it is essential to the lives of people who suffer from a disease. The International Classification of Functioning, Disability and Health (ICF) can help in designing a functioning profile of a patient, identifying needs for rehabilitation plans and measuring the results of an intervention.
Objective: To identify the outcome measurement instruments reported in clinical studies in muscular dystrophies (MDs) and provide an ICF content analysis.
Heat source recognition sensor mimicking the thermosensation function of human skin.
Innovation (Camb)
September 2024
Department of Materials Science and Engineering, Southern University and Science and Technology, Shenzhen 518055, China.
The human skin maintains a comfortable and healthy somatosensory state by sensing different aspects of the thermal environment, including temperature value, heat source, energy level, and duration. However, state-of-the-art thermosensors only measure basic temperature values, not the full range of the thermosensation function of human skin. Here, we propose a heat source recognition () sensor of poly(butyl acrylate)-lithium bis(n-fluoroalkylsulfonyl)imide (PBA-Li:FSI; = 1, 3, 5), which enables response to temperature, pressure, and proximity stimulus signals based on the relaxation behavior of the ionic gel and distinguished between different types of heat sources (i.
View Article and Find Full Text PDFAn extracellular vesicle based hypothesis for the genesis of the polycystic kidney diseases.
Extracell Vesicle
December 2024
The Jared Grantham Kidney Institute at the University of Kansas Medical Center, Department of Nephrology and Hypertension, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Autosomal dominant polycystic kidney (ADPKD) disease is the commonest genetic cause of kidney failure (affecting 1:800 individuals) and is due to heterozygous germline mutations in either of two genes, and . Homozygous germline mutations in are responsible for autosomal recessive polycystic kidney (ARPKD) disease a rare (1:20,000) but severe neonatal disease. The products of these three genes, (polycystin-1 (PC1 4302(3)aa)), (polycystin-2 (PC2 968aa)) and (fibrocystin (4074aa)) are all present on extracellular vesicles (EVs) termed, PKD-exosome-like vesicles (PKD-ELVs).
View Article and Find Full Text PDFShifting Trend of Protein Consumption in Southeast Asia: Toward Health, Innovation, and Sustainability.
Curr Dev Nutr
October 2024
Clinical Nutrition Research Centre (CNRC), Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology and Research (A∗STAR), Singapore, Singapore.
Complementing discourse following a February 2023 event on dietary protein needs in Southeast Asia (SEA), this symposium report summarizes the region's protein intake, while simultaneously examining the impact of dietary shift toward complementary and alternative proteins and their health implications. It highlights the importance of protein quality in dietary evaluations, optimal intake, and sustainability, advocating for environmentally conscious protein production and innovation in future foods. Discussion points, expert opinions, national nutrition data, and relevant literature, addressing protein intake and quality, their impact on human health, and various technologies for future foods production, have been included.
View Article and Find Full Text PDFEvaluation of IRF7 mRNA and its Association with Promoter Methylation in Kashmiri (North-Indian) Patients with Systemic Sclerosis: A Case-Control Study.
Mediterr J Rheumatol
December 2024
Department of Immunology & Molecular Medicine.
Introduction: The interferon regulatory factor 7 (IRF7), a member of the IRF family of transcription factors, plays a major role in the regulation of numerous aspects of an immune response and has increasingly been surveyed to determine the aetiology and pathogenesis of systemic sclerosis (SSc). Objective: This study aimed to investigate the transcriptional levels of IRF7 mRNA in peripheral blood mononuclear cells (PBMCs) and the impact of promoter methylation on IRF7 mRNA expression in SSc patients compared to healthy controls.
Methods: PBMCs were obtained from confirmed 40 naïve SSc cases and 20 healthy controls for IRF-7 expression and methylation analysis.
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