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Alcohol use among Croatian adolescents: the alignment of 13-year-old and 15-year-old girls with boys, and the impact of the COVID-19 pandemic.
Croat Med J
December 2024
Maja Valentić, Tijardovićeva 8, 10104 Zagreb,
Aim: To determine age and gender patterns of alcohol use among Croatian pupils and assess whether alcohol use was associated with factors related to school, peers, family, and the COVID-19 pandemic.
Methods: Data were collected from the 2022 Health Behavior in School-aged Children cross-sectional study conducted in Croatia involving 5338 pupils. Pearson χ2 test and multivariate logistic regression were performed.
Synthesis of Chiral Saturated Heterocycles Bearing Quaternary Centers via Enantioselective β-C(sp)-H Activation of Lactams.
J Am Chem Soc
January 2025
Department of Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, United States.
The development of catalytic methods for the synthesis of enantiopure saturated heterocycles has been a long-standing challenge in asymmetric catalysis. We describe the first highly enantioselective palladium-catalyzed βC(sp)-H arylation and olefination of lactams for the preparation of various chiral N-heterocycles bearing quaternary carbon centers. The presence of strongly electron-withdrawing groups on the chiral bifunctional MPAThio ligand is crucial to the reactivity of weakly coordinating lactams.
View Article and Find Full Text PDFThe effect of apathy on quality of life and caregiver burden in patients with dementia.
Cogn Neuropsychiatry
January 2025
Behavioral Neurology and Movement Disorders Unit, Department of Neurology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye.
Introduction: Apathy is one of the common neuropsychiatric symptoms in people with dementia (PwD). The aim of this study is to determine the impact of apathy on the patient's quality of life (QoL) and caregiver's burden among PwD.
Methods: Sample of this cross-sectional descriptive study consisted of 88 PwD attending the outpatient clinic of a university hospital in Istanbul and their family caregivers.
Identity change metaphors in public blogs written by people living with dementia and their care partners.
Dementia (London)
January 2025
Department of Psychology, University of Wisconsin Oshkosh, Oshkosh, WI, USA.
Dementia and the associated stigma pose unique threats to the identity of persons with dementia, triggering attempts to cope with resulting identity changes. We explore identity change narratives and metaphors written by people with dementia and care partners in public blog posts. These metaphors reflect bloggers' motivation to adapt, adjust, and cope with identity change and their motives to challenge common misunderstandings of dementia as a complete loss of selfhood.
View Article and Find Full Text PDFGanoderic Acid A Alleviates Severe Acute Pancreatitis by Modulating Gut Homeostasis and Inhibiting TLR4-NLRP3 Signaling.
J Agric Food Chem
January 2025
Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China.
Background Severe acute pancreatitis (SAP) manifests as a critical state marked by acute abdominal symptoms, often associated with intestinal barrier dysfunction, exacerbating SAP retroactively. Ganoderic acid A (GAA) demonstrates anti-inflammatory properties in various inflammatory disorders. Nonetheless, its potential therapeutic impact on SAP and the underlying mechanisms remain unexplored.
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