The investigation of the functional activity of the kidneys in old hypertensives revealed that the changes in partial functions of the kidneys observed in hypertension tend to diminish the effectiveness of the mechanisms controlling arterial blood pressure. This means that this disorder of function constitutes an important link in the pathogenesis of hypertension. Mild and severe disturbances of renal function in old hypertensives can be regarded as evidence of the growing role of the kidneys in the pathogenesis of late-onset hypertension. They are attributable to pre-existing physiological changes taking place in the kidneys at advanced age and to the declining reliability of the kidneys in the homeostatic control of arterial blood pressure.
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