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Aminopeptidasic Enzymes as Early Biomarkers of Cardiac Surgery-Associated Acute Kidney Injury and Long-Term Events.
Biomolecules
August 2024
Area of Physiology, Department of Health Sciences, University of Jaén, 23071 Jaén, Spain.
Background: Diagnosis of acute kidney injury (AKI) relies on serum creatinine (SCr) changes. This study investigated if urinary aminopeptidases are early and predictive biomarkers of cardiac surgery-associated AKI (CSA-AKI).
Methods: Glutamyl aminopeptidase (GluAp), alanyl aminopeptidase (AlaAp), dipeptidyl peptidase-4 (DPP4), proteinuria, albuminuria, N-acetyl-β--glucosaminidase (NAG), and neutrophile gelatinase-associated lipocalin (NGAL) were measured in urine samples from 44 patients at arrival in the intensive care unit (ICU) after cardiac surgery.
Phosphocalcic metabolism and its potential association with biomarkers of kidney disease in dogs with spontaneous hyperadrenocorticism.
Vet J
June 2024
Ecole Nationale Vétérinaire d'Alfort, CHUVA, Service de médecine interne, Maisons-Alfort F-94700, France; Ecole nationale vétérinaire d'Alfort, Univ Paris Est Créteil, INSERM, IMRB, Maisons-Alfort 94700, France. Electronic address:
Article Synopsis
- The study investigates how hyperadrenocorticism (HAC) affects calcium and phosphate metabolism in dogs, linking these changes to kidney health.
- It compares 54 dogs across three groups: those with HAC, those with other illnesses, and healthy dogs, measuring various serum and urinary biomarkers.
- Results show that dogs with HAC have significantly higher serum phosphate levels, urinary calcium excretion, and altered Vitamin D metabolism, suggesting a connection between HAC, proteinuria, and kidney function.
Are silymarin and N-acetylcysteine able to prevent liver damage mediated by multiple factors? Findings against ethanol plus LPS-induced liver injury in mice.
J Biochem Mol Toxicol
January 2024
Postgraduate Program in Pharmaceutical Sciences, Universidade do Vale do Itajaí, Itajaí, Santa Catarina, Brazil.
This study investigated the effect of N-acetylcysteine (NAC) and silymarin (SIL) in the liver of mice exposed to ethanol and lipopolysaccharides (LPS). Mice were divided into four groups (n = 6): naive, vehicle, NAC (200 mg/kg), and SIL (200 mg/kg). Treatments were given orally (po) once daily for 10 days.
View Article and Find Full Text PDFDietary lipids management: are there any benefits from the prevention and treatment of 4T1 murine breast carcinoma?
An Acad Bras Cienc
August 2023
Universidade Federal de Juiz de Fora, Departmento de Ciências Básicas da Vida, Campus Governador Valadares, Rua São Paulo, 745, Centro, 35010-180 Governador Valadares, MG, Brazil.
This study investigated the effect of vegetable and fish oils with different n-3 / n-6 PUFAS ratios on the lipoprotein profile and on the development of murine breast cancer 4T1. Female Balb/c mice (6-7 weeks) received diets containing 4.0% fat during seven weeks.
View Article and Find Full Text PDFThe Protective Potential of L. Berry Extract against Cadmium-Induced Kidney Damage: A Study in an Animal Model of Human Environmental Exposure to This Toxic Element.
Int J Mol Sci
July 2023
Department of Pathology and Veterinary Diagnostics, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 159C Street, 02-776 Warsaw, Poland.
The impact of cadmium (Cd) on the function and structure of the kidney and the potential protective effect of an extract from L. berries were investigated in a rat model of low- and moderate-level environmental exposure to this heavy metal (1 and 5 mg Cd/kg feed for up to 24 months). The sensitive biomarkers of Cd-induced damage to the kidney tubules (N-acetyl-β-D-glucosaminidase (NAG), alkaline phosphatase (ALP), β2-microglobulin (β2-MG), and kidney injury molecule-1 (KIM-1) in the urine), clinically relevant early markers of glomerular damage (albumin in the urine and creatinine clearance), and other markers of the general functional status of this organ (urea, uric acid, and total protein in the serum and/or urine) and Cd concentration in the urine, were evaluated.
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