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Contributions of Both the Eastman Entropy of Transfer and Electric Double Layer to the Electromotive Force of Ionic Thermoelectric Supercapacitors.
ACS Appl Mater Interfaces
January 2025
Global Zero Emission Research Center, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba 16-1 Onogawa, Tsukuba, Ibaraki 305-8569, Japan.
Recently, ionic thermoelectric supercapacitors have gained attention because of their high open circuit voltages, even for ions that are redox inactive. As a source of open circuit voltage (electromotive force), an asymmetry in electric double layers developed by the adsorption of ions at the electrode surfaces kept at different temperatures has previously been proposed. As another source, the Eastman entropy of transfer, which is related to the Soret coefficient, has been considered.
View Article and Find Full Text PDFStage-specific efficacy of osimertinib in treatment-naïve EGFR-mutant non-small cell lung cancer according to baseline genetic alterations in circulating tumor DNA.
Invest New Drugs
January 2025
Center for Biomedical Sciences, Wakayama Medical University, Wakayama, Japan.
The impact of clinical stage on the effectiveness of osimertinib for epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer (NSCLC) remains unexamined. We investigated osimertinib therapeutic efficacy variation between stage IVA or lower and stage IVB EGFR mutation-positive lung cancers, focusing on differences in pretreatment co-occurring genetic alterations in circulating tumor DNA. This was a secondary analysis of the ELUCIDATOR study, a multicenter prospective observational study in Japan that assessed the mechanisms underlying resistance to osimertinib as a first-line treatment for advanced NSCLC with EGFR mutations.
View Article and Find Full Text PDFProspective validation of ORACLE, a clonal expression biomarker associated with survival of patients with lung adenocarcinoma.
Nat Cancer
January 2025
Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, London, UK.
Human tumors are diverse in their natural history and response to treatment, which in part results from genetic and transcriptomic heterogeneity. In clinical practice, single-site needle biopsies are used to sample this diversity, but cancer biomarkers may be confounded by spatiogenomic heterogeneity within individual tumors. Here we investigate clonally expressed genes as a solution to the sampling bias problem by analyzing multiregion whole-exome and RNA sequencing data for 450 tumor regions from 184 patients with lung adenocarcinoma in the TRACERx study.
View Article and Find Full Text PDFFeasibility of substituting soda pulping with high consistency kneaded chemi mechanical pulping for discarded oyster farming bamboo scaffolding.
Sci Rep
January 2025
Department of Forestry, National Chung Hsing University, Taichung, 40227, Taiwan, ROC.
In the previous study, discarded oyster farming bamboo scaffolding (BS) demonstrated the potential for application in pulping and papermaking through the soda pulping process. However, soda pulping involves high temperatures and chemical dosages. Therefore, this study develops an alternative pulping process to lower temperature and chemical demands by utilizing a high-consistency kneader (HCK), simultaneously promoting the utilization of BS in pulping and papermaking.
View Article and Find Full Text PDFThe lightweight design of steel pistons for diesel engines based on thermo-mechanical characteristics.
Sci Rep
January 2025
Yunnan Key Laboratory of Plateau Emission of Internal Combustion Engines, Kunming Yunnei Power CO., LTD., Kunming City, 650200, People's Republic of China.
Traditional aluminum-silicon alloy pistons are gradually replaced by steel pistons, which has become the trend of future diesel engine development. However, the efficient design and broad application of steel pistons are limited by the higher density of steel. For this reason, a new lightweight design method for steel pistons in diesel engines was proposed in this paper.
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