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High-intensity interval training to improve cardiorespiratory fitness in a patient with frailty and multimorbidity: A case report.
Physiother Theory Pract
January 2025
Department of Surgical Sciences, Dunedin School of Medicine, Dunedin, New Zealand.
Background: Low cardiorespiratory fitness predicts worse postoperative outcomes, exacerbated by age and frailty. Preoperative High-Intensity Interval Training (HIIT) improves cardiorespiratory fitness and postoperative outcomes but is challenging to implement in frailty due to perceived risks.
Purpose: The aim of this case report was to demonstrate feasibility of HIIT in a patient with frailty and multimorbidity.
Prostate cancer-selective anticancer action of an oxindole derivative via HO-1-mediated disruption of metabolic reprogramming.
Chem Biol Interact
January 2025
College of Pharmacy, Yeungnam University, Gyeongsan 38541, Republic of Korea. Electronic address:
Prostate cancer, the second leading cause of cancer-related mortality in men, exhibits distinct metabolic reprogramming involving zinc and citrate metabolism. This study investigated whether targeting this unique metabolic profile could offer an effective therapeutic approach. A series of novel oxindole derivatives were synthesized and evaluated for their inhibitory effects on transcription factors (TFs) and antiproliferative activity across various cancer cell lines.
View Article and Find Full Text PDFCharacteristics of supervised injection site clients and factors associated with requiring overdose intervention, Montreal, Canada, 2018-2022.
Int J Drug Policy
January 2025
Centre de recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM), 900 rue St-Denis, Montréal, Québec H2X 0A9, Canada; Department of Emergency and Family Medicine, Université de Montréal, 2900 blvd Edouard Montpetit, Montréal, Québec H3T 1J4, Canada; National Drug and Alcohol Research Centre, UNSW Sydney, Anzac Parade, Kensington NSW 2052, Australia. Electronic address:
Background: Supervised injection sites (SIS) offer a hygienic environment in which people can inject drugs under observation; as such, these harm reduction services have been on the forefront of the overdose epidemic. We sought to understand factors predictive of an overdose requiring an emergency response intervention at SIS in Montréal, Canada.
Methods: We used administrative data from all four Montréal SIS from 1 March 2018 - 31 October 2022 to first calculate the rate of onsite overdose requiring intervention (e.
Physiological effects of suspended sediments on marine fish across habitat, development, and behavioral factors.
Mar Pollut Bull
January 2025
School of Earth and Environmental Sciences & Research Institute of Oceanography, Seoul National University, Seoul 08826, Republic of Korea; Research Institute of Oceanography, Seoul National University, Seoul 08826, Republic of Korea; Center for Convergence Coastal Research, Seoul National University, Siheung-si, Gyeonggi-do 15011, Republic of Korea. Electronic address:
This study evaluated the physiological responses of four marine fish species (Lateolabrax japonicus, Sebastes schlegelii, Platichthys stellatus, and Paralichthys olivaceus) to suspended sediments (SS) generated by marine sand mining. Using oxygen consumption rate (OCR), osmolality, and mortality as endpoints, the effects of SS concentrations ranging from 0 to 10,000 mg L were assessed. L.
View Article and Find Full Text PDFPromoting SO and OH Generation from Sulfate Solution toward Efficient Electrochemical Oxidation of Organic Contaminants at a B/N-Doped Diamond Flow-Through Electrode.
Environ Sci Technol
January 2025
Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education, China), School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, China.
Electrochemical oxidation via in situ-generated reactive oxygen species (ROS) is effective for the mineralization of refractory organic pollutants. However, the oxidation performance is usually limited by the low yield and utilization efficiency of ROS. Herein, a B/N-doped diamond (BND) flow-through electrode with enhanced SO/OH generation and utilization was designed for electrochemical oxidation of organic pollutants in sulfate solution.
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