Experiments were conducted on rats. The effects of hormones administered into the IV ventricle (central action) and intramuscularly (peripheral action) were compared. In studying the excitability of the hypothalamus, gonadotropic activity of the hypophysis, the structure of the adenohypophysis and the ovaries, and also of the homeostatic mechanisms realizable in compensatory hypertrophy of the ovaries there were revealed significant differences in the results of action of the same hormone with different methods of its administration.
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