Twenty-four-hour urinary hydroxyproline excretion (HOP) (normal values: 6-22 mg/day/m2) was measured by the Hypronosticon test in 50 untreated patients with plasma cell myeloma. At diagnosis, HOP was elevated in 36 of 50 patients (72%) with a mean value of 35.9 mg/day/m2. Extent of bone lesions and clinical stage were accurately assessed in all patients. Higher HOP values were found in patients with a higher degree of bone lesions (multiple lytic areas and/or destruction of skeletal segments). According to clinical stages, HOP was very elevated only in stage III (mean value: 43.7); in stages I and II the mean value (25.2) was just above the normal range. Our data indicate that HOP in multiple myeloma at diagnosis is closely related to the extension of skeletal lesions and that during the clinical course it may be useful in the follow-up of bone disease.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/030089168407000309 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hydroxyproline in Urine Microvesicles as a Biomarker of Fibrosis in the Renal Transplant Patient.
Biomedicines
December 2024
Area of Physiology, Department of Health Sciencies, University of Jaen, 23071 Jaen, Spain.
: Interstitial fibrosis/tubular atrophy in kidney transplantation is an unspecific lesion induced by immune and non-immune factors, which determines the progression of chronic kidney disease. Hydroxyproline is an imino acid that is part of the molecule of collagen. The aim of this study was to assess hydroxyproline in urine microvesicles as a marker of fibrosis in the renal transplant patient.
View Article and Find Full Text PDFMetagenomics and metabolomics to investigate the effect of Amygdalus mongolica oil on intestinal microbiota and serum metabolites in rats.
Phytomedicine
January 2025
Department of Pharmacy, Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014040, China; Institute of Bioactive Substance and Function of Chinese Materia Medica and Mongolian Medicine, Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014040, China. Electronic address:
Background: Renal fibrosis (RF) is an inevitable consequence of multiple manifestations of progressive chronic kidney diseases (CKDs). Mechanism of Amygdalus mongolica (Maxim.) in the treatment of RF needs further investigation.
View Article and Find Full Text PDFAmeliorative effects of Edaravone against Valproic Acid-Induced kidney damage.
J Mol Histol
November 2024
Department of Chemistry, Faculty of Engineering, Istanbul University-Cerrahpaşa, 34320, Avcilar-Istanbul, Türkiye.
Valproic acid (VPA) is a well-known and increasingly documented antiepileptic drug that has been widely used in the treatment of epilepsy and/or epilepsy-related disorders. Prolonged clinical use of VPA has been reported to cause side effects such as nephrotoxicity. Edaravone (EDA) is a powerful free radical scavenger.
View Article and Find Full Text PDFHuman glyoxylate metabolism revisited: New insights pointing to multi-organ involvement with implications for siRNA-based therapies in primary hyperoxaluria.
J Inherit Metab Dis
January 2025
Department of Pediatric Nephrology, Emma Children's Hospital, Amsterdam, The Netherlands.
Article Synopsis
- - Glyoxylate, a toxic byproduct of metabolism, is rapidly converted into oxalate, necessitating effective detoxification systems in various cell compartments, with key enzymes AGT and GRHPR involved in this process.
- - Mutations in genes encoding AGT and GRHPR lead to primary hyperoxaluria types 1 and 2, respectively, while a defect in the HOGA1 enzyme is associated with type 3, all resulting in serious kidney issues such as nephrocalcinosis and potential kidney failure.
- - Recent advancements in therapies, particularly RNAi-based treatments (lumasiran and nedosiran), are improving outcomes for primary hyperoxaluria, with nedosiran targeting all
Hydroxyprolyl-Glycine in 24 H Urine Shows Higher Correlation with Meat Consumption than Prolyl-Hydroxyproline, a Major Collagen Peptide in Urine and Blood.
Nutrients
October 2024
Department of Food Science and Nutrition, Faculty of Human Life and Environment, Nara Women's University, Nara 630 8506, Japan.
Urinary collagen peptides, the breakdown products of endogenous collagen, have been used as biomarkers for various diseases. These non-invasive biomarkers are easily measured via mass spectrometry, aiding in diagnostics and therapy effectiveness. The objective of this study was to investigate the effects of consuming collagen-containing meat on collagen peptide composition in human blood and urine.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!