The bite of the elapid snake Aspidelaps scutatus has previously been regarded as medically unimportant. We report a case in which its bite resulted in neurotoxicity.
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A confirmed human fatality due to envenomation by the Kunene Coral Snake (Aspidelaps lubricus cowlesi) in Namibia.
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AfriMed e.V., Mühlheim, Germany; Erongo Park, Omaruru, Namibia. Electronic address:
Shield-nose and Coral snakes (Aspidelaps spp.) are medium sized venomous snakes found throughout southern Africa. Little is known about the venom of these snakes and its clinical relevance, as human bites are uncommon.
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Venom Evolution Lab, School of Biological Sciences, University of Queensland, St Lucia, QLD 4072, Australia.
Prey-selective venoms and toxins have been documented across only a few species of snakes. The lack of research in this area has been due to the absence of suitably flexible testing platforms. In order to test more species for prey specificity of their venom, we used an innovative taxonomically flexible, high-throughput biolayer interferometry approach to ascertain the relative binding of 29 α-neurotoxic venoms from African and Asian elapid representatives (26 spp.
View Article and Find Full Text PDFNeurotoxic envenomation by the South African coral snake (Aspidelaps lubricus): A case report.
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Division of Medical Toxicology, Department of Emergency Medicine, University of Pittsburgh School of Medicine, Iroquois Building Suite 400, 3600 Forbes Ave, Pittsburgh, PA 15213, USA. Electronic address:
The South African coral snake (Aspidelaps lubricus, Elapidae) has not previously been reported to cause any neurotoxic envenomations in humans. We recently treated a 44-year-old man who was bitten twice, once in each hand, by a captive South African coral snake (Aspidelaps lubricus) while feeding the female snake who had recently laid eggs. Approximately one hour after receiving the bite, he developed vomiting, respiratory failure requiring mechanical ventilation, and paralysis of the bulbar and upper extremity muscles, with retention of voluntary motor control in the lower extremities.
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While envenoming by the southern African shield-nosed or coral snakes (genus Aspidelaps) has caused fatalities, bites are uncommon. Consequently, this venom is not used in the mixture of snake venoms used to immunise horses for the manufacture of regional SAIMR (South African Institute for Medical Research) polyvalent antivenom. Aspidelaps species are even excluded from the manufacturer's list of venomous snakes that can be treated by this highly effective product.
View Article and Find Full Text PDFNeurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling.
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AIMMS Division of BioMolecular Analysis, Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands. Electronic address:
Article Synopsis
- This paper outlines a new method using microfluidic high-resolution screening (HRS) to create neurotoxicity profiles for snake venoms, focusing on their interaction with the acetylcholine binding protein (AChBP).
- The study found that elapid snake venoms showed strong neurotoxic profiles with identifiable components, while viperid and colubrid venoms showed minimal activity, establishing a correlation between venom interactions and the severity of neurotoxicity in human envenomations.
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