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Anti-MDA5 Positive Juvenile Dermatomyositis With Macrophage Activation Syndrome: A Case Report.
Cureus
December 2024
Pediatric Medicine, Tawam Hospital, Abu Dhabi, ARE.
Article Synopsis
- There are various inflammatory myopathies, including juvenile dermatomyositis (JDM), which can cause muscle inflammation and weakness, with macrophage activation syndrome (MAS) being a severe complication, though it is not frequently reported.
- A case study of a six-year-old girl with proximal muscle weakness and skin manifestations, leading to a JDM diagnosis, showed elevated lab markers and confirmed muscle involvement through MRI.
- The girl initially improved with steroid therapy, but later tested positive for anti-MDA5 antibodies, indicating a worse prognosis and highlighting the importance of recognizing MAS as a possible complication in JDM patients with these antibodies.
A 72-year-old man with acute lung injury and anti-melanoma differentiation-associated gene 5 antibody: A case report.
Respir Med Case Rep
August 2024
Department of Medicine, Jefferson Einstein Hospital, Philadelphia, PA, USA.
Anti-melanoma differentiation-associated gene 5 antibody (anti-MDA-5 Ab) is associated with amyopathic dermatomyositis (DM). These patients are particularly at high-risk for developing acute and rapidly progressive interstitial lung disease (ILD). Given the lack of muscle-related symptoms, along with its sudden onset and rapid clinical progression, the diagnosis of anti-MDA-5 Ab + ILD represents a challenge for clinicians.
View Article and Find Full Text PDFFurther expanding the phenotype of anti-Ku antibody associated disease in children and adolescents.
Neuromuscul Disord
July 2024
Department of Pediatrics, Division of Pediatric Rheumatology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Anti-Ku autoantibodies are associated with several autoimmune inflammatory diseases. We aimed to review our anti-Ku positive pediatric patients in this study. Four pediatric patients (all female) who had anti-Ku positivity were included (Patients 1-2-3 with idiopathic inflammatory myopathy (IIM); Patient 4 with chronic urticaria).
View Article and Find Full Text PDFTuberculosis among children and adolescents with rheumatic diseases - case series.
Pediatr Rheumatol Online J
November 2023
Pediatric Pulmonology Unit, Instituto de Puericultura e Pediatria Martagão Gesteira, Universidade Federal do Rio de Janeiro (UFRJ), Rua Bruno Lobo, 50 - Cidade Universitária, Rio de Janeiro, Brazil.
Article Synopsis
- - The study investigated children and adolescents with tuberculosis (TB) who also had rheumatic diseases (RD) at a reference center in Rio de Janeiro between 1995 and 2022, revealing a higher occurrence of TB in this population compared to the general youth demographic.
- - Out of 15 patients studied, 53% were female, with a mean age of 7.1 years at RD diagnosis and 9.8 years at TB diagnosis, showcasing a variety of RD types and TB cases, including both pulmonary and extrapulmonary forms.
- - The findings highlight the necessity of timely TB diagnosis and treatment in RD patients undergoing immunosuppressive therapies, especially in countries like Brazil where TB prevalence is high. *
JAK Inhibitors as Potential Therapeutic Strategy for the Dilemma of Psoriasis Concurrent with Dermatomyositis in the SARS-CoV-2 Era.
Clin Cosmet Investig Dermatol
April 2023
Department of Dermatology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China.
Dermatomyositis is a rare inflammatory disease with potentially life-threatening systemic involvement that is treated with systemic corticosteroids. However, when psoriasis coexists with dermatomyositis, the administration of corticosteroids may exacerbate psoriasis after withdrawal, posing a treatment dilemma. Our search of the literature revealed 14 cases where various treatments were used, including methotrexate, corticosteroids, cyclosporin, ustekinumab, mycophenolate mofetil, and azathioprine.
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