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Compound Tongyang Fumai decoction improves quality of life in sick sinus syndrome: a randomized controlled study.
J Tradit Chin Med
December 2024
Cardiovascular Department, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China.
Objective: To evaluate the efficacy of Tongyang Fumai decoction (, TYFM) on the quality of life (QOL) as a complementary therapy for sick sinus syndrome (SSS).
Methods: This randomized controlled study involved 224 patients with symptomatic SSS. Patients were randomly assigned to either the TYFM group or the control group (receiving theophylline sustained-release tablets).
Insulin mitigates acute ischemia-induced atrial fibrillation and sinoatrial node dysfunction ex vivo.
JCI Insight
November 2024
Departments of Cardiovascular Medicine and Physiology and Biomedical Engineering and Center for Regenerative Biotherapeutics, Mayo Clinic Arizona, Scottsdale, Arizona, USA.
Article Synopsis
- Acute atrial ischemia is linked to postoperative atrial fibrillation (POAF), but its mechanisms are not fully understood.
- An experiment mimicking POAF showed that 25 minutes of ischemia increased the incidence of atrial fibrillation, particularly affecting the right atrium more than the left.
- Insulin treatment before and during reperfusion significantly reduced vulnerability to AF by improving the heart's electrical properties and calcium handling, suggesting a potential therapeutic approach for preventing POAF.
Adaptive control of cardiac rhythms.
Sci Rep
October 2024
Smart Systems Lab, Department of Mechanical and Materials Engineering, University of Turku, Turku, Finland.
Cardiac rhythms are related to heart electrical activity, being the essential aspect of the cardiovascular physiology. Usually, these rhythms are represented by electrocardiograms (ECGs) that are useful to detect cardiac pathologies. Essentially, the heart activity starts in the sinoatrial node (SA) node, the natural pacemaker, propagating to the atrioventricular node (AV), and finally reaching the His-Purkinje complex (HP).
View Article and Find Full Text PDFDevelopment of learning-based predictive models for radiation-induced atrial fibrillation in non-small cell lung cancer patients by integrating patient-specific clinical, dosimetry, and diagnostic information.
Radiother Oncol
December 2024
Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine, Seoul, South Korea. Electronic address:
Article Synopsis
- Radiotherapy for non-small cell lung cancer can lead to cardiac issues like atrial fibrillation, prompting a study to create predictive models using patient-specific data.
- Two cohorts (321 and 187 patients) were analyzed using both machine learning and deep learning approaches, overcoming class imbalance with synthetic oversampling and focusing on the most influential features during model training.
- The hybrid deep learning model outperformed the machine learning model in predicting atrial fibrillation, with maximum doses to the heart and sinoatrial node identified as key predictive factors across both internal and external datasets.
Essential Role of the RIα Subunit of cAMP-Dependent Protein Kinase in Regulating Cardiac Contractility and Heart Failure Development.
Circulation
December 2024
Université Paris-Saclay, Inserm, Signaling and Cardiovascular Pathophysiology, UMR-S1180 (I.B., M.G.-R., M.D., A.B., A.V., D.M., S.B., J.C., P.L., S.K., M.D., S.G., W.P.d.V., P.M., A.D., J.-J.M., J.-P.B., V.A., J.L., R.F., A.-M.G., G.V.), Orsay, France.
Background: The heart expresses 2 main subtypes of cAMP-dependent protein kinase (PKA; type I and II) that differ in their regulatory subunits, RIα and RIIα. Embryonic lethality of RIα knockout mice limits the current understanding of type I PKA function in the myocardium. The objective of this study was to test the role of RIα in adult heart contractility and pathological remodeling.
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