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Clinical features and risk factors of invasive pulmonary aspergillosis in interstitial lung disease patients.
BMC Pulm Med
December 2024
Department of Respiratory and Critical Care Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.
Article Synopsis
- Invasive pulmonary aspergillosis (IPA) is increasingly common in patients with interstitial lung disease (ILD), leading to high mortality rates, prompting a study to analyze the clinical features and risk factors associated with IPA in these patients.
- The study evaluated 353 hospitalized ILD patients, identifying 58 cases of IPA, primarily characterized by symptoms like cough and dyspnea, and revealed key CT findings such as honeycombing and consolidation.
- Significant risk factors for IPA included lymphopenia and honeycombing, with a 90-day survival rate of 74.1% among patients treated with antifungal drugs.
Coccidiomycosis is a regional disease with global importance, with both an expanding endemic area and population, as well as increasing travel. Although unusual, it should be considered in patients with a travel history to endemic areas, even when immunocompetent and outside the usual incubation period. We present a case of isolated ankle septic arthritis which required an aggressive multidisciplinary surgical approach as well as antibiotic therapy.
View Article and Find Full Text PDFClinical practice pattern of Pneumocystis pneumonia prophylaxis in systemic lupus erythematosus: a cross-sectional study from lupus registry of nationwide institutions (LUNA).
Arthritis Res Ther
November 2024
Department of Rheumatology, Kakogawa Central City Hospital, Kakogawa, Japan.
Background: Pneumocystis jirovecii pneumonia (PCP) is an opportunistic infection in patients undergoing immunosuppressive therapy, such as glucocorticoid (GC) medication, for systemic autoimmune diseases like systemic lupus erythematosus (SLE). Despite the confirmed effectiveness of PCP prophylaxis, its clinical administration, especially in conjunction with GC dosage, remains unclear. We aimed to describe the clinical practice of PCP prophylaxis in association with SLE in Japan, evaluate the relationship between GC dosage and PCP prophylaxis, and explore the practice patterns associated with PCP prophylaxis.
View Article and Find Full Text PDF[Medical clinical diagnostics for indoor mould exposure - Update 2023 (AWMF Register No. 161/001)].
Pneumologie
October 2024
Labor Dr. Wisplinghoff.
This article is an abridged version of the updated AWMF mould guideline "Medical clinical diagnostics in case of indoor mould exposure - Update 2023", presented in July 2023 by the German Society of Hygiene, Environmental Medicine and Preventive Medicine (Gesellschaft für Hygiene, Umweltmedizin und Präventivmedizin, GHUP), in collaboration with German and Austrian scientific medical societies, and experts. Indoor mould growth is a potential health risk, even if a quantitative and/or causal relationship between the occurrence of individual mould species and health problems has yet to be established. There is no evidence for a causal relationship between moisture/mould damage and human diseases, mainly because of the ubiquitous presence of fungi and hitherto inadequate diagnostic methods.
View Article and Find Full Text PDFClinical performance evaluation of the BioFire Joint Infection Panel.
J Clin Microbiol
November 2024
Microbiology Service, Department of Laboratory Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Article Synopsis
- The BioFire Joint Infection (JI) Panel improves the diagnosis of joint infections by quickly detecting multiple bacteria and fungi, as well as resistance markers, from synovial fluid samples.
- An article by Moran et al. discusses real-world uses of the panel, showcasing its effectiveness and efficiency in clinical settings.
- While the panel has advantages like quick results and identifying tough pathogens, it also has limitations, especially in detecting some organisms not included in the test.
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