A method is described for the determination of morphine in serum. Separation and quantitation are performed by reversed-phase high performance liquid chromatography with electrochemical detection. A sample size of 100 microL or less is required for detection of concentrations as low as 1 to 2 ng/mL. In trials with standard solutions, recovery was 75%. The between-run and within-run coefficients of variation were 7.3% (over the range of 5 to 200 ng/mL) and 9.1% (at 5 ng/mL), respectively.
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| http://dx.doi.org/10.1093/jat/8.3.135 | DOI Listing |
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Article Synopsis
- The study aimed to evaluate how tourniquet usage impacts surgical time, muscle injury, and pain after ACL reconstruction.
- Researchers conducted a systematic review of randomized controlled trials, extracting data on various factors such as operative time and postoperative pain across seven studies with 471 participants.
- Findings indicated that tourniquet use reduced surgery duration but was linked to increased muscle injury markers (higher CPK levels) and greater postoperative pain and blood loss.
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