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Geometry of obstructed pathway regulates upstream navigational pattern of sperm population.
Lab Chip
January 2025
Department of Food Science and Technology, Cornell University, Ithaca, NY 14853, USA.
Sperm navigation through the complex microarchitecture of the fallopian tube is essential for successful fertilization. Spatiotemporal structural alteration due to folded epithelium or muscle contractions in the fallopian tube changes the geometry of the sperm pathways. The role of structural complexity in sperm navigational patterns has been investigated for single sperm cells but has not been fully addressed at the population level.
View Article and Find Full Text PDFA Pilot Trial of Tongue Reconstruction Using the Chimeric Innervated Vastus Lateralis Muscle and Antero-Lateral Thigh Free Flap.
Head Neck
January 2025
Department of Head and Neck Surgery, Chris O'Brien Lifehouse, Sydney, Australia.
Background: Subtotal and total glossectomies for advanced tongue cancer result in significant speech- and swallow-related morbidity, impairing quality of life. This prospective pilot study compares the safety and functional outcomes associated with using a chimeric innervated muscle and fasciocutaneous flap for soft tissue reconstruction.
Materials And Methods: A prospective, non-randomized controlled pilot study evaluated a standardized technique for tongue reconstruction using a chimeric innervated vastus lateralis muscle and anterolateral thigh fasciocutaneous flap.
Overexpression of Drosophila NUAK or Constitutively-Active Formin-Like Promotes the Formation of Aberrant Myofibrils.
Cytoskeleton (Hoboken)
January 2025
Department of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas, USA.
Muscle development and maintenance is central to the normal functioning of animals. Muscle tissues exhibit high levels of activity and require the dynamic turnover of proteins. An actomyosin scaffold functions with additional proteins comprising the basic contractile subunit of striated muscle, known as the sarcomere.
View Article and Find Full Text PDFLeptin drives glucose metabolism to promote cardiac protection via OPA1-mediated HDAC5 translocation and Glut4 transcription.
Funct Integr Genomics
January 2025
Department of Cardiology, Guizhou Provincial People`s Hospital, 83 Zhongshan East Road, Guiyang City, 550002, Guizhou Province, China.
Metabolic reprogramming, the shifting from fatty acid oxidation to glucose utilization, improves cardiac function as heart failure (HF) progresses. Leptin plays an essential role in regulating glucose metabolism. However, the crosstalk between leptin and metabolic reprogramming is poorly understood.
View Article and Find Full Text PDFDisplacement MMG-based estimation of dynamic muscle viscoelasticity in the quadriceps during passive pedaling.
Sci Rep
January 2025
Graduate School of Interdisciplinary Science and Engineering of Health Systems, Okayama University, Okayama, 700-0082, Japan.
We explore the correlation between muscle viscoelasticity and displacement mechanomyography (DMMG) during passive joint movement. Current methods for assessing muscle viscoelasticity (which is essential for rehabilitation and sports conditioning) are limited in terms of simplicity, objectivity, and portability. We introduce a novel methodology employing DMMG during passive pedaling to evaluate these properties.
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