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Age-associated interplay between zinc deficiency and Golgi stress hinders microtubule-dependent cellular signaling and epigenetic control.
Dev Cell
December 2024
Department of Biological Sciences, Ajou University, Suwon 16499, South Korea. Electronic address:
Golgi abnormalities have been linked to aging and age-related diseases, yet the underlying causes and functional consequences remain poorly understood. This study identifies the interaction between age-associated zinc deficiency and Golgi stress as a critical factor in cellular aging. Senescent Golgi bodies from human fibroblasts show a fragmented Golgi structure, associated with a decreased interaction of the zinc-dependent Golgi-stacking protein complex Golgin45-GRASP55.
View Article and Find Full Text PDFThe impact of age on comparative diagnostic accuracy of temporal artery thermometers and non-contact infrared thermometers for fever detection: a systematic review and meta-analysis.
BMC Infect Dis
January 2025
School of Nursing, China Medical University, 100, Sec. 1, Jingmao Rd, Taichung, 406040, Taiwan.
Background: Non-invasive temporal artery thermometers (TATs) and non-contact infrared thermometers (NCITs) are increasingly used in community settings to measure body temperature. Existing research predominantly focuses on pediatric populations, yet the accuracy and precision of TATs and NCITs for fever screening across age groups remain unclear. This study aims to assess age-related differences in the diagnostic accuracy of TATs and NCITs for fever detection.
View Article and Find Full Text PDFCharacteristics of Peripheral Intravenous Catheter Cannulation in Older Japanese Inpatients.
J Infus Nurs
January 2025
Author Affiliations: Faculty of Nursing, Department of Nursing, Josai International University, Chiba, Japan (Mss Kitada and Tateno; Drs Ninomiya and Kabashim); Faculty of Pharmaceutical Sciences, Department of Medical Pharmacy, Josai International University, Chiba, Japan (Dr Yamamura); Behavioral Science, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan (Dr Hori).
Age-related physiological changes affect various aspects of peripheral intravenous catheter (PIVC) cannulation. However, the characteristics of PIVCs, especially in older patients, have been poorly investigated. In the current cross-sectional observational study, PIVC sizes, PIVC sites, the number of attempts until successful insertion, and the degree of venodilation upon insertion among hospital inpatients aged ≥65 years were investigated, along with measurements of the vessel diameter and depth using ultrasound.
View Article and Find Full Text PDFAge-related differences in eye blink-related neural activity and functional connectivity during driving.
Heliyon
January 2025
Department of Ergonomics, Leibniz Research Centre for Working Environment and Human Factors, 44139, Dortmund, Germany.
Article Synopsis
- Driving involves complex coordination that deteriorates with age, affecting cognitive and motor functions.
- A study compared blink behavior and neural responses in younger and older adults during reactive and proactive driving tasks, revealing that younger participants had shorter blink durations and more efficient neural processing.
- Functional connectivity analysis indicated that younger adults exhibit stronger network integration in various brain areas, while older adults showed signs of compensatory mechanisms in attention networks, suggesting adaptability in response to cognitive demands.
Young Psoriatic Patients Respond Faster to Dimethyl Fumarate: Age-related Differences in Efficacy and Adverse Events.
J Clin Aesthet Dermatol
December 2024
All authors are with the Section of Dermatology, DISSAL, at the University of Genoa, Ospedale-Policlinico San Martino, IRCCS in Genova, Italy and IRCCS Ospedale Policlinico San Martino in Genova, Italy.
Article Synopsis
- Dimethyl fumarate (DMF) is an oral medication approved for treating moderate-to-severe plaque psoriasis in adults.
- The study evaluated 92 patients without prior systemic therapy to see how their demographics and medical characteristics affected DMF's efficacy and side effects.
- Results showed significant improvement in psoriasis symptoms within 4 weeks, with younger patients responding better to treatment, while factors like gender and BMI didn't significantly influence side effects.
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