Solanum tuberosum agglutinin (STA) binds to the surface of human platelets and leads to their agglutination. Lectin staining shows that 125I-STA most intensely labels a major platelet membrane glycoprotein identified as GPIIIa followed by GPIV . STA does not induce release reaction, TXB2 formation or platelet protein phosphorylation. Since STA-induced agglutination is independent of intracellular metabolism of platelets, STA may prove to be a useful tool to explore the clinical condition in which the composition of platelet membrane protein is altered.
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| http://dx.doi.org/10.1016/0006-291x(84)90683-1 | DOI Listing |
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