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Effects of genetic mutations on left ventricular myocardial mechanics and fibrosis patterns in hypertrophic cardiomyopathy.
Sci Rep
January 2025
Division of Cardiology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
Myocyte disarray and fibrosis are underlying pathologies of hypertrophic cardiomyopathy (HCM) caused by genetic mutations. However, the extent of their contributions has not been extensively evaluated. In this study, we investigated the effects of genetic mutations on myofiber function and fibrosis patterns in HCM.
View Article and Find Full Text PDFIntraprocedural transthoracic EChocardiography to facilitate Left Bundle Branch Pacing: EC-LBBP.
Heart Rhythm
December 2024
Geisinger Heart Institute, Wilkes Barre, Pennsylvania.
Background: Left bundle branch (LBB) pacing (LBBP) has gained rapid adoption. Evidence for direct LBB capture has varied from 30%-95% depending on the criteria.
Objective: The purpose of this study was to assess the feasibility and efficacy of intraprocedural transthoracic echocardiographic guidance to achieve LBB capture.
A Cadaveric Case Report of a Rare Atrial Septal Lipoma.
Cureus
October 2024
Department of Anatomical Sciences, William Carey University College of Osteopathic Medicine, Hattiesburg, USA.
Article Synopsis
- Primary cardiac tumors (PCTs) like myxomas and lipomas are rare, with lipomas being soft fat masses that can lead to diagnostic challenges.
- Lipomatous hypertrophy of the atrial septum (LHAS) is a benign condition linked to aging and obesity, distinct from true cardiac lipomas.
- A case of a true atrial septal lipoma discovered during heart dissection is detailed, highlighting its potential effects on heart function and contributing to the scarce literature on benign primary cardiac tumors.
Predialysis central arterial waveform and blood pressure changes during hemodialysis.
Sci Rep
October 2024
Department of Nephrology and Hypertension, Dokkyo Medical University, Mibu, Tochigi, Japan.
To investigate the predictive value of the central arterial waveform for intradialytic blood pressure (BP) change, a total of 152 hemodialysis patients (mean age 68 years) on a thrice-weekly hemodialysis schedule were enrolled, and at both the first and second session of the week, BP and central arterial waveform were measured every 30 min during hemodialysis. In both sessions, a 1-standard deviation increase in baseline subendocardial viability ratio (SEVR), an index of subendocardial perfusion, as well as in baseline systolic BP (SBP) was an independent predictor of maximum SBP decrease ≥ 30 mmHg during hemodialysis. When divided into four groups based on the respective median level of SEVR in the SBP ≥ median and SBP < median groups, intradialytic SBP change was different among the subgroups.
View Article and Find Full Text PDFPreventive impact of probiotic supplements on heart injury and inflammatory indices in a rat model of myocardial infarction: histopathological and gene expression evaluation.
APMIS
January 2025
Dietary Supplements and Probiotic Research Center, Alborz University of Medical Sciences, Karaj, Iran.
Although there is a bulk of evidence on the favorable effect of probiotics on the cardiac system, their role in the management of myocardial infarction is not clear. Three viable probiotic bacterial strains, namely Lactobacillus reuteri, Bifidobacterium longum, and Bifidobacterium lactis, were gavaged to the rats daily for 28 days prior to the induction of myocardial injury. Myocardial injury was induced by the use of isoproterenol (ISO) in the probiotics, control and sham groups.
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