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Dispersal promotes stability and persistence of exploited yeast mutualisms.
ISME J
January 2025
Biology Department, University of Massachusetts Boston, Boston, MA 02125.
Multi-species mutualistic interactions are ubiquitous and essential in nature, yet they face several threats, many of which have been exacerbated in the Anthropocene era. Understanding the factors that drive the stability and persistence of mutualism has become increasingly important in light of global change. Although dispersal is widely recognized as a crucial spatially explicit process in maintaining biodiversity and community structure, knowledge about how the dispersal of mutualists contributes to the persistence of mutualistic systems remains limited.
View Article and Find Full Text PDFBackground: Enriching and detecting Alzheimer's disease (AD) biomarkers in cerebral spinal fluid (CSF) or blood samples are increasingly applied in the AD diagnosis and monitoring of disease progression and treatment response. The accuracy of these processes is dependent on the sensitivity and specificity of capturing and quantifying AD biomarkers, e.g.
View Article and Find Full Text PDFBackground: Subtle cognitive decline in the prodromal stages of Alzheimer's disease (AD), encompassing both significant memory concerns (SMC) and mild cognitive impairment (MCI), presents a crucial diagnostic hurdle. This challenge stems from the inherent difficulty in both detecting the nuanced neurocognitive aberrations and visualizing the corresponding brain alterations, particularly within the hippocampus, on conventional magnetic resonance imaging (MRI). Consequently, current clinical diagnostic procedures remain arduous and necessitate substantial clinical expertise.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Background: Long-COVID is characterized by persistent symptoms post-infection with SARS-CoV-2. This condition includes neurological manifestations and has been proposed as a potential risk factor for the development of dementia. Individuals presenting with dementia due to Alzheimer's disease have dysfunctional brain metabolism, including metabolic brain network (MBN) hypoconnectivity.
View Article and Find Full Text PDFBackground: Liquid biopsy for Alzheimer's disease (AD) biomarkers in cerebral spinal fluid (CSF) or blood samples is becoming a significant sector in the management of AD and AD related dementia (ADRD). Whereas different types of molecules, such as small molecules, peptides, and antibodies, have been used as ligands for targeting AD biomarkers/pathologies such as amyloid beta peptides (Aβs), current liquid biopsy approaches mostly use antibodies. However, the activity and affinity of the antibodies can vary depending on the source and preparation as well as the stability in storage.
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