Histochemical study of the choroid plexus of the control and hydrated dogs injected with pituitrin solution (25 IU/kg bw) into the cerebral ventricle via a special cannula has demonstrated the ventricular surface of the choroid epithelium to bear compounds belonging to the class of glycosaminoglycans (GAG), primarily containing hyaluronic acid. The animals exposed to hydration showed an overt increase, whereas those treated with pituitrin a reduction in the content of GAG as compared with controls. The data obtained suggest that GAG contained by the choroid plexus are involved in the mechanism by which the rate of CSF formation is regulated.
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