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Modular Access to C2'-Aryl/Alkenyl Nucleosides with Electrochemical Stereoselective Cross-Coupling.
Angew Chem Int Ed Engl
December 2024
Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, Zhangjiang Institute for Advanced Study, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China.
Article Synopsis
- Chemically modified oligonucleotides are gaining attention for their stability in biological systems, but existing synthesis methods for modifications, especially at the C2'-position, lack efficiency and selectivity.
- A new electrochemical nickel-catalyzed cross-coupling method allows for the creation of diverse C2'-α-aryl/alkenyl nucleosides with excellent stereoselectivity and broad compatibility.
- The study demonstrates that oligonucleotides with C2'-aryl modifications have improved resistance to degradation and maintain effective cellular uptake, suggesting their potential in therapeutic applications.
Mechanisms of survival of trimethoprim-sulfamethoxazole-induced thymineless death.
mBio
November 2024
Division of Pulmonary and Sleep Medicine, Department of Pediatrics, University of Washington, Seattle, Washington, USA.
Trimethoprim-sulfamethoxazole (SXT) is commonly used to treat diverse infections, including those associated with cystic fibrosis (CF) pulmonary disease. Studies with found that SXT impairs tetrahydrofolate production, leading to DNA damage, stress response induction, and accumulation of reactive oxygen species (ROS) in a process known as thymineless death (TLD). TLD survival can occur through the uptake of exogenous thymidine, countering the effects of SXT; however, a growing body of research has implicated central metabolism as another potentially important determinant of bacterial survival of SXT and other antibiotics.
View Article and Find Full Text PDFComparison of safety and effectiveness of antiretroviral therapy regimens among pregnant women living with HIV at preconception or during pregnancy: a systematic review and network meta-analysis of randomized trials.
BMC Infect Dis
April 2024
HIV/STI Surveillance Research Center, WHO Collaborating Center for HIV, Surveillance Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran.
Background: Mother-to-child transmission is the primary cause of HIV cases among children. Antiretroviral therapy (ART) plays a critical role in preventing mother-to-child transmission and reducing HIV progression, morbidity, and mortality among mothers. However, after more than two decades of ART during pregnancy, the comparative effectiveness and safety of ART medications during pregnancy are unclear, and existing evidence is contradictory.
View Article and Find Full Text PDFCircSEPT9 promotes breast cancer progression by regulating PTBP3 expression via sponging miR-625-5p.
Thorac Cancer
April 2024
Oncology Discipline Group, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou City, China.
Background: Breast cancer (BC) is a common malignancy which threatens the health of women. Circular RNAs (circRNAs) are critical factors in multiple cancers, including BC. The aim of this experiment was to investigate the molecular mechanisms of circRNA Septin 9 (circSEPT9) in the progression of BC.
View Article and Find Full Text PDFElimination of 15N-thymidine after oral administration in human infants.
PLoS One
January 2024
Division of Pediatric Cardiology, Pediatric Institute for Heart Regeneration and Therapeutics (I-HRT), UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, United States of America.
Background: We have developed a new clinical research approach for the quantification of cellular proliferation in human infants to address unanswered questions about tissue renewal and regeneration. The approach consists of oral 15N-thymidine administration to label cells in S-phase, followed by Multi-isotope Imaging Mass Spectrometry for detection of the incorporated label in cell nuclei. To establish the approach, we performed an observational study to examine uptake and elimination of 15N-thymidine.
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