AI Article Synopsis
- - The authors introduced a new method to analyze how clinical and pharmacokinetic parameters respond to a preliminary dose of a psychotropic drug, aiming to predict therapy effectiveness.
- - This method was tested in a multicenter study of clozapine (leponex) across ten research centers in six countries, involving 136 patients.
- - Results showed that the method accurately predicted the therapy’s effectiveness in 84% of cases, aligning with the actual outcomes of treatment.
Article Abstract
To help individual prediction of the therapy efficacy, the authors elaborated a new method for analyzing the response of the clinical and pharmacokinetic parameters to the pre-treatment administration of the test dose of a psychotropic drug. The above approach was employed in a multicentre clinical-pharmacokinetic study of leponex ( clozapin ) which involved ten research centers from six countries and a total of 136 patients. On the basis of the clinical and pharmacokinetic parameters, a cumulative index was obtained and its prediction potentialities were established. The prognostic assessment of the affectiveness obtained on the basis of this approach was in agreement with the real efficacy of the course therapy in 84% of all cases.
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