Multicentre international studies make it possible to amass rapidly and reliably the necessary amount of representative data allowing for the verification of the results obtained by different scientific schools. They also represent the most effective approach to the search for attaining the mutual understanding among specialists of different scientific schools and for the elaboration of uniform clinical outlooks . Guidelines were developed to be adhered to while organizing and conducting multicentre psychopharmacological studies. The authors describe the general scheme and the basic stages of a multicentre psychopharmacological study of leponex which involved specialists from ten centres from six countries (CSSR, GDR, HPR, PRB , PPR, USSR).
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Dev Cogn Neurosci
December 2024
School of Psychological Science, University of Bristol, UK.
It is well established that faces evoke a distinct neural response in the adult and infant brain. Past research has focused on how the infant face-sensitive ERP components (N290, P400, Nc) reflect different aspects of face processing, however there is still a lack of understanding of how these components reflect face familiarity and how they change over time. Further, there are only a few studies on whether these neural responses correlate with other aspects of development, such as infant temperament.
View Article and Find Full Text PDFEnzyme Microb Technol
December 2024
University of Galway, University Road, Galway H91 TK33, Ireland; Science Foundation Ireland MaREI Centre for Energy, Climate and Marine, Environmental Research Institute, University College Cork, Cork, Ireland.
The present study proposes a biorefinery of the macroalgae Ulva, focusing on evaluating two different morphologies of the species (foliose and tubular) during acidogenic fermentation in fed-batch reactors. Stage 1 of the study evaluates lyophilised foliose and tubular Ulva, whilst Stage 2 analyses the impact of ulvan extraction on volatile fatty acids yield and changes in carbohydrate availability. Acetic, propionic, and butyric acids were produced from each substrate, with peak concentrations of total VFAs recorded at 2179.
View Article and Find Full Text PDFLung Cancer
January 2025
Internal Medicine III, Wakayama Medical University, Wakayama, Japan.
Objectives: The lack of definitive biomarkers presents a significant challenge for chemo-immunotherapy in extensive-stage small-cell lung cancer (ES-SCLC). We aimed to identify key genes associated with chemo-immunotherapy efficacy in ES-SCLC through comprehensive gene expression analysis using machine learning (ML).
Methods: A prospective multicenter cohort of patients with ES-SCLC who received first-line chemo-immunotherapy was analyzed.
J Exp Child Psychol
January 2025
Graduate School of Human Sciences, Osaka University, Suita-shi, Osaka 565-0871, Japan.
Persistence, characterized by continued efforts in the face of difficulties, is crucial for children's success. Many researchers have aimed to identify the factors that improve persistence. Previous research has found that children who use more strategies to solve a challenging task tend to exhibit greater persistence, suggesting that providing instructions for multiple strategies may enhance their persistence.
View Article and Find Full Text PDFBiomed Phys Eng Express
January 2025
Institute for Integrated Radiation and Nuclear Science, Kyoto University, 2-1010 Asashiro-nishi, Kumatori-cho, Sennan-gun, Osaka, 590-0494, JAPAN.
Clinical research in boron neutron capture therapy (BNCT) has been conducted worldwide. Currently, the Monte Carlo (MC) method is the only dose calculation algorithm implemented in the treatment planning system for the clinical treatment of BNCT. We previously developed the MC-RD calculation method, which combines the MC method and the removal-diffusion (RD) equation, for fast dose calculation in BNCT.
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