The effect of a single insulin injection on the reaction of the coronary vessels to adrenaline, noradrenaline, and acetylcholine was studied in experiments on dogs. Insulin induces a decrease of arterial pressure and of the resistance of the coronary and peripheral vessels reduces the reflex cholinergic and beta-adrenergic reactions of dilatation of the coronary vessels, and promotes alpha-adrenergic reactions in intracoronary administration of adrenaline and noradrenaline. Insulin also weakens the immediate cholinergic reactions of the coronary vessels in stimulation of the effector systems with acetylcholine.
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