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Oral Kaposi sarcoma in Brazil: a case series of 40 patients highlighting a significant health burden.
Oral Surg Oral Med Oral Pathol Oral Radiol
December 2024
Oral Diagnosis Department, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil; Service of Oral Pathology, João de Barros Barreto University Hospital, Federal University of Pará, Pará, Brazil. Electronic address:
Objective: The aim of this study was to provide a comprehensive clinicopathological analysis of oral Kaposi sarcoma (KS) cases and examine its relationship with HIV-related immunosuppression.
Study Design: Paraffin-embedded tissue blocks of patients microscopically diagnosed with oral KS were retrieved from three oral and maxillofacial pathology files. Data including clinical, laboratory, microscopic and immunohistochemical findings and treatment employed were retrieved.
Successful treatment of recurrent refractory Kaposi's sarcoma in AIDS: a case report.
Front Oncol
December 2024
The Second Infectious Disease Department, Xixi Hospital of Hangzhou, Hangzhou, China.
Article Synopsis
- Kaposi's sarcoma (KS) is a soft tissue lesion linked to HHV-8 infection, often seen in immunocompromised patients, especially those with AIDS, and has a high mortality rate.
- A case report details a patient with AIDS-KS who relapsed after initial chemotherapy, but achieved complete remission with a PD-1 inhibitor, indicating its effectiveness in treatment.
- The PD-1 inhibitor was well-tolerated, improved the patient's immune system, and suggests a promising approach for managing AIDS-KS.
[Pulmonary Kaposi sarcoma after lung transplantation: a case report and literature review].
Zhonghua Jie He He Hu Xi Za Zhi
January 2025
Department of Organ Transplantation, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou510120, China.
To investigate the clinical features, diagnosis, and treatment of pulmonary Kaposi sarcoma (KS) after lung transplantation. A case of pulmonary KS after bilateral lung transplantation was retrospectively analyzed. Two key words "Kaposi sarcoma" and "lung transplant*" were used to search for relevant literature in SinoMed, Wanfang Data, CNKI, PubMed, Embase, Cochrane Library and Web of Science, with a cut-off date of July 31, 2024.
View Article and Find Full Text PDFA Unique Case of Metastatic Oral Kaposi Sarcoma in an HIV-Negative Patient.
Ear Nose Throat J
January 2025
Department of Otolaryngology-Head & Neck Surgery, Lehigh Valley Health Network, Allentown, PA, USA.
Kaposi's sarcoma (KS) is a tumor involving blood vessels and lymphatic tissue. It is caused by human herpes virus-8, typically in HIV infection in individuals with AIDS. There are 4 major types of KS including classic, endemic, immunosuppression, and AIDS-related.
View Article and Find Full Text PDFDiagnosis and Management of Kaposi Sarcoma-Associated Herpesvirus Inflammatory Cytokine Syndrome in Resource-Constrained Settings: A Case Report and an Adapted Case Definition.
Trop Med Infect Dis
December 2024
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Kaposi sarcoma-associated herpes virus (KSHV), also known as human herpes virus 8 (HHV-8), is the primary etiologic cause of Kaposi sarcoma (KS) and KSHV Inflammatory Cytokine Syndrome (KICS). Patients with KICS demonstrate symptoms of systemic inflammation, high KSHV viral load, elevation of inflammatory markers, and increased mortality. Management requires rapid diagnosis, treatment of underlying HIV, direct treatment of KS, and addressing the hyperimmune response.
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