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Development and validation of a nomogram to predict survival in septic patients with heart failure in the intensive care unit.
Sci Rep
January 2025
China Academy of Chinese Medical Sciences, Beijing, China.
Heart failure is a common complication in patients with sepsis, and individuals who experience both sepsis and heart failure are at a heightened risk for adverse outcomes. This study aims to develop an effective nomogram model to predict the 7-day, 15-day, and 30-day survival probabilities of septic patients with heart failure in the intensive care unit (ICU). This study extracted the pertinent clinical data of septic patients with heart failure from the Critical Medical Information Mart for Intensive Care (MIMIC-IV) database.
View Article and Find Full Text PDFGP73 reinforces cytotoxic T-cell function by regulating HIF-1α and increasing antitumor efficacy.
J Immunother Cancer
January 2025
Department of Clinical Laboratory, The Third Medical Center of Chinese PLA General Hospital, Beijing, Beijing, China
Background: Immunotherapy that targets immune checkpoints has achieved revolutionary success, but its application in solid tumors remains limited, highlighting the need for reliable enhancement of the efficacy of immunotherapy. Golgi protein 73 (GP73), a Golgi membrane protein, has been implicated in various cellular processes, including immune regulation. Recent studies suggested that GP73 may play a role in modulating the immune response in patients with cancer.
View Article and Find Full Text PDFEngineering the Ratios of Nanoparticles Dispersed in Triphasic Nanocomposites for Biomedical Applications.
ACS Appl Mater Interfaces
January 2025
Department of Bioengineering, University of California, Riverside, 900 University Avenue, Riverside, California 92521, United States.
Polymer/ceramic nanocomposites integrated the advantages of both polymers and ceramics for a wide range of biomedical applications, such as bone tissue repair. Here, we reported triphasic poly(lactic--glycolic acid) (PLGA, LA/GA = 90:10) nanocomposites with improved dispersion of hydroxyapatite (HA) and magnesium oxide (MgO) nanoparticles using a process that integrated the benefits of ultrasonic energy and dual asymmetric centrifugal mixing. We characterized the microstructure and composition of the nanocomposites and evaluated the effects of the HA/MgO ratios on degradation behavior and cell-material interactions.
View Article and Find Full Text PDFSubpopulation-specific gene expression in uncovers distinct metabolic adaptations to wine fermentation.
Curr Res Food Sci
December 2024
Department of Genetics, Physiology and Microbiology, Unit of Microbiology, Faculty of Biological Sciences, Complutense University of Madrid, 28040, Madrid, Spain.
Gene expression is the first step in translating genetic information into quantifiable traits. This study analysed gene expression in 23 strains across six subpopulations of , shaped by anthropization, under winemaking conditions to understand the impact of adaptation on transcriptomic profiles and fermentative performance, particularly regarding lactic acid production. Understanding the gene expression differences linked to lactic acid production could allow a more rational address of biological acidification while optimizing yeast-specific nutritional requirements during fermentation.
View Article and Find Full Text PDFModelling energy metabolism dysregulations in neuromuscular diseases: A case study of calpainopathy.
Heliyon
December 2024
Laboratoire de Biométrie et de Biologie Évolutive, UMR CNRS 5558 Université Claude Bernard Lyon 1, 69622, Villeurbanne cedex, France.
Biological modelling helps understanding complex processes, like energy metabolism, by predicting pathway compensations and equilibrium under given conditions. When deciphering metabolic adaptations, traditional experiments face challenges due to numerous enzymatic activities, needing modelling to anticipate pathway behaviours and orientate research. This paper aims to implement a constraint-based modelling method of muscular energy metabolism, adaptable to individual situations, energy demands, and complex disease-specific metabolic alterations like muscular dystrophy calpainopathy.
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