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Objective: To investigate the effect of cervical margin relocation with four different injectable restorative materials on the fracture resistance of molars receiving mesio-occluso-distal CAD/CAM nanoceramic onlay restorations.

Materials And Methods: One hundred and five sound mandibular molars received a standardized mesio-occluso-distal onlay preparation, with cervical margins located 2 mm apical to the cemento-enamel junction. The molars were randomly allocated into five groups (n = 21) according to the cervical relocating materials used: Group I had no cervical margin relocation; Group II used a highly viscous glass ionomer; Group III used a highly-filled injectable resin composite; Group IV used a resin-modified glass ionomer; and Group V used a bioactive ionic resin.

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Fe-N-C catalysts are considered promising substitutes for Pt-based catalysts at the cathode in direct methanol fuel cells (DMFCs) owing to their great methanol tolerance. However, Fe-N-C-based DMFCs commonly suffer from a decreased performance under extremely high methanol concentrations and exhibit poor stability, while the underlying mechanism remains controversial. In this study, a self-degradation phenomenon in a passive Fe-N-C-based DMFC was investigated in detail.

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Safety and recommendation of voriconazole for invasive pulmonary aspergillosis in severe liver disease patients: a retrospective cohort study.

BMC Infect Dis

January 2025

Department of Respiratory and Critical Care Medicine, Beijing Youan Hospital, Capital Medical University, 8 Xitoutiao, Youanmenwai, Fengtai District, Beijing, 100069, China.

Background: Invasive pulmonary aspergillosis (IPA) is a common opportunistic infection in patients with severe liver disease (SLD), which increases the mortality of patients. The aim of this study was to evaluate the efficacy and safety of voriconazole for IPA in patients with SLD and explore an optimal antifungal regimen.

Methods: This was a retrospective cohort study of SLD patients diagnosed with proven or probable IPA at Beijing Youan Hospital, Capital Medical University between January 1, 2012 to January 31, 2023.

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Cu-EAB zeolite catalyst: A promising candidate with excellent SO poisoning resistance for NH-SCR reaction.

J Hazard Mater

January 2025

MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, IGCME, Sun Yat-sen University, Guangzhou 510006, China. Electronic address:

In this work, we synthesized Cu-EAB catalysts with an EAB topology for the NH-SCR of NO and evaluated their resistance to SO poisoning for the first time. The Cu-EAB catalyst showed superior NO conversion and selectivity for N, along with a notable tolerance to high space velocities and SO, outperforming the commercial Cu-CHA catalyst. This enhanced resistance was attributed to the Cu species formation at the 2.

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Induction of Antigen-Specific Tolerance in a Multiple Sclerosis Model without Broad Immunosuppression.

ACS Nano

January 2025

Division of Pharmacoengineering and Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.

Multiple sclerosis (MS) is a severe autoimmune disorder that wreaks havoc on the central nervous system, leading to a spectrum of motor and cognitive impairments. There is no cure, and current treatment strategies rely on broad immunosuppression, leaving patients vulnerable to infections. To address this problem, our approach aims to induce antigen-specific tolerance, a much-needed shift in MS therapy.

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