It has been shown in rat experiments that low-energy laser (transcutaneous action on liver tissue) increases the functional activity of intact hepatocytes, activating the regeneration of injured parenchyma.
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Thyme and Oregano Oil Potential Therapeutics against Malathion Toxicity through Biochemical, Histological, and Cytochrome P450 1A2 Activities in Male Wistar Rats.
Animals (Basel)
October 2024
Department of Animal Productions, Faculty of Agriculture, Al-Azhar University, Assiut 71524, Egypt.
The widespread use of malathion may offer several hazards to humans and animals; additionally, many medicinal plants provide what is known as a broad antitoxicity treatment. This study was carried out to investigate hazardous biochemical and histological reactions to MOP and evaluate the effectiveness of TEO and OEO essential oils in restoring normal physiological conditions after MOP exposure by measuring enzyme-specific activity for Cytochrome P450 1A2 (CYP1A2). One hundred and twenty rats were divided into six groups of twenty animals each: (i) C - MOP served as the control group, (ii) C + MOP treated with 5 mg/kg/BW of Malathion-D10, (iii) TEO treated with 100 mg/kg/BW of oregano essential oil, (iv) TEO treated with 100 mg/kg/BW of thyme essential oil, (v) MOP + OEO treated with 5 mg/kg/BW of Malathion-D10 and 100 mg/kg/BW of oregano essential oil, and (vi) MOP + TEO treated with 5 mg/kg/BW of Malathion-D10 and 100 mg/kg/BW of thyme essential oil.
View Article and Find Full Text PDFCromolyn sodium and masitinib combination inhibits fibroblast-myofibroblast transition and exerts additive cell-protective and antioxidant effects on a bleomycin-induced in vitro fibrosis model.
Pharmacol Res Perspect
October 2024
Vocational High School of Health Services, Department of Medical Laboratory Techniques, Alanya Alaaddin Keykubat University, Alanya, Turkey.
Article Synopsis
- * A study explored combining two medications, masitinib and cromolyn sodium, to see if together they could help fight against tissue damage in the lungs caused by IPF.
- * The results showed that this combination could protect lung cells and might be a promising new treatment, potentially needing lower doses and causing fewer side effects.
Baccharoides anthelmintica (L.) Moench: A Review on Ethnomedicinal, Phytochemical, Pharmacological and Toxicological Profile.
Chem Biodivers
June 2024
Laboratory of Pharmacognosy and Phytochemistry, Department of Pharmacy, Indira Gandhi National Tribal University, Amarkantak, Anuppur District-484887, India.
Baccharoides anthelmintica (L.) Moench is a popular medicinal plant with a long history of use in several traditional remedies to cure a variety of diseases including; its effect on the central nervous system, gastrointestinal tract, metabolism, kidneys, gynecology, skin diseases, and general health. The present review aims to provide the latest, organized information on toxicological, pharmacological, phytochemical, and ethnomedicinal applications of Baccharoides anthelmintica.
View Article and Find Full Text PDFPomegranate peel, chokeberry leaves and Ironwort extract as novel natural inhibitors of amylin aggregation and cellular toxicity in pancreatic β cells.
Biophys Chem
January 2024
Department of Biological Sciences, The George Washington University, Washington, DC 20052, USA. Electronic address:
Impeding or reducing human amylin aggregation and/or its toxicity can be key to preventing pancreatic islet amyloidosis and β-cell loss in patients with Type 2 Diabetes Mellitus (T2DM). Here, Punica granatum (pomegranate) peel, Sideritis raeseri (ironwort) and Aronia melanocarpa (chokeberry) leaf extracts, were tested for their novel anti-aggregative and antitoxic properties in human amylin (hIAPP) treated rat pancreatic insulinoma (INS) cells. The protein aggregation (Th-T) assay revealed an inhibitory trend of all three plant extracts against amylin aggregates.
View Article and Find Full Text PDFEvents Leading to the Establishment of Pregnancy and Placental Formation: The Need to Fine-Tune the Nomenclature on Pregnancy and Gestation.
Int J Mol Sci
October 2023
Center for Perinatal and Reproductive Medicine, University of Perugia, 06156 Perugia, Italy.
Today, there is strong and diversified evidence that in humans at least 50% of early embryos do not proceed beyond the pre-implantation period. This evidence comes from clinical investigations, demography, epidemiology, embryology, immunology, and molecular biology. The purpose of this article is to highlight the steps leading to the establishment of pregnancy and placenta formation.
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