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Understanding the role of the gut microbiome in solid tumor responses to immune checkpoint inhibitors for personalized therapeutic strategies: a review.
Front Immunol
January 2025
Personalized Diet Research Group, Korea Food Research Institute, Wanju-gun, Jeollabuk-do, Republic of Korea.
Immunotherapy, especially immune checkpoint inhibitor (ICI) therapy, has yielded remarkable outcomes for some patients with solid cancers, but others do not respond to these treatments. Recent research has identified the gut microbiota as a key modulator of immune responses, suggesting that its composition is closely linked to responses to ICI therapy in cancer treatment. As a result, the gut microbiome is gaining attention as a potential biomarker for predicting individual responses to ICI therapy and as a target for enhancing treatment efficacy.
View Article and Find Full Text PDFRed cell distribution width/platelet ratio predicts decompensation of metabolic dysfunction-associated steatotic liver disease-related compensated advanced chronic liver disease.
World J Gastroenterol
January 2025
Department of Internal Medicine, Azienda Ospedaliero-Universitaria of Modena (2023), Modena 41126, Italy.
Prognostication of compensated advanced chronic liver disease (cACLD) is of paramount importance for the physician-and-patient communication and for rational clinical decisions. The paper published by Dallio reports on red cell distribution width (RDW)/platelet ratio (RPR) as a non-invasive biomarker in predicting decompensation of metabolic dysfunction-associated steatotic liver disease (MASLD)-related cACLD. Differently from other biomarkers and algorithms, RPR is inexpensive and widely available, based on parameters which are included in a complete blood count.
View Article and Find Full Text PDFPredation can alter diverse ecological processes, including host-parasite interactions. Selective predation, whereby predators preferentially feed on certain prey types, can affect prey density and selective pressures. Studies on selective predation in infected populations have primarily focused on predators preferentially feeding on infected prey.
View Article and Find Full Text PDFPB2 and PA mutations contribute to the pathogenicity of mouse-adapted pdmH1N1-Venus reporter influenza A virus in a mammalian model.
Front Microbiol
January 2025
Department of Biopharmacy, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, China.
Influenza A viruses have been a threat to human health for the past 100 years. Understanding the dynamics and pathogenicity of the influenza viruses is of great value in controlling the influenza pandemic. Fluorescent protein-carrying recombinant influenza virus is a substantially useful tool for studying viral characteristics and high-throughput screening .
View Article and Find Full Text PDFTunable photoluminescence and energy transfer in Dy and Eu co-doped NaCaGd(WO) phosphors for pc-WLED applications.
Dalton Trans
January 2025
Yildiz Technical University, Faculty of Chemical and Metallurgical Engineering, Department of Metallurgical and Materials Engineering, Glass Research and Development Laboratory, Istanbul, 34220, Türkiye.
Elevated temperatures can lead to reabsorption and color drift, compromising the quality of phosphor-converted white light-emitting diode (pc-WLED) devices. To ensure the performance of WLEDs under these conditions, it is essential to develop luminescent materials that maintain stable color. Consequently, there is a pressing need for single-phase white-emitting phosphors with robust chromatic stability.
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