AI Article Synopsis
- The study aimed to find the minimum alveolar concentrations (MAC) for halothane and nitrous oxide in pigs, as this data was previously unavailable.
- The research revealed that the MAC values for pigs were significantly higher than those for other mammals, with halothane at 1.25% and nitrous oxide at 277%.
- Factors influencing these variances included differences among species, age, body temperature, sympathetic activity, and the methods used in the experiments.
Article Abstract
To compare anesthetic effects using a swine model, we needed to know the minimum alveolar concentrations (MAC) of halothane and nitrous oxide that produce anesthesia in the pig. This information does not exist in literature. Furthermore, MAC varies considerably among species: by more than 60% for halothane, and by more than 200% for nitrous oxide. Therefore, using eight young swine, we determined mean (+/- SEM) MAC values for halothane (1.25 +/- 0.04% of one atmosphere) and nitrous oxide (277 +/- 18% of one atmosphere). These values are higher than values reported for other mammals. Factors possibly accounting for this variability include interspecies differences, age, body temperature, increased sympathetic activity, and differences in methodology.
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