Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Poly-Dha Sequences as -polypeptides: An Original Mechanistic Postulate Leads to the Discovery of a Long-Acting Vasodilator KU04212.
JACS Au
October 2024
Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66045, United States.
The construction of polypeptides was revolutionized by Merrifield's solid-phase synthesis more than half a century ago. Herein, we explore a completely different approach to making peptides. We test an original mechanistic postulate wherein a single peptide made entirely of dehydroalanine (Dha) residues can give rise to regio- and stereodefined peptides by iterative conjugate addition of one- or two-electron nucleophiles.
View Article and Find Full Text PDFEnhanced Degradability of Thiol-Ene Composites through the Inclusion of Isosorbide-Based Polycarbonates.
ACS Appl Mater Interfaces
July 2024
Royal Institute of Technology, School of Chemical Science and Engineering, Department of Fibre and Polymer Technology, KTH, Teknikringen 56-58, 100 44 Stockholm, Sweden.
Article Synopsis
- * Researchers are exploring alternatives like a new hydrophobic composite material containing TATO, which offers strong fixation but lacks degradability.
- * To enhance degradability, allyl-functionalized polycarbonates were added, especially aPC3, which significantly improved degradation rates and maintained mechanical properties, outperforming previous composites in strength and stiffness during testing.
Dessecting the toxicological profile of polysorbate 80 (PS80): comparative analysis of constituent variability and biological impact using a zebrafish model.
Eur J Pharm Sci
July 2024
State Key Laboratory of Natural Medicines, NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients, and Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China. Electronic address:
Polysorbate 80, commonly abbreviated as PS80, is a widely used pharmaceutical excipient renowned for its role as a solubilizer and stabilizer in drug formulations. Although PS80 is essential for various pharmaceutical applications, particularly in the formulation of injectable drugs, it has been implicated in a range of adverse reactions. However, due to the complexity of the composition of PS80, the differences in the types and contents of the constituents of PS80 from different manufacturers increase the probability or likelihood of their uneven quality.
View Article and Find Full Text PDFReaction Pathways in Carbonates and Esters.
ChemSusChem
December 2023
Department of Environmental Sciences, Informatics and Statistics, Ca' Foscari University of Venice, Campus Scientifico, via Torino 155, 30172, Venezia Mestre, Italy.
This review reports on the competition/collaboration among intertwined base-catalyzed acyl cleavage bimolecular mechanism (B 2)/base-catalyzed alkyl cleavage bimolecular mechanism (B 2) or the related acid catalyzed mechanisms A 2/A 2 and A 1 concerning Carbonates chemistry also in comparison with Esters reactivity. A consistent analysis of the experimental data so far available in the literature led to proposing a theoretical Model outlining the differences in energy profiles among the above-mentioned reaction mechanisms. The reactions involving Carbonates are so tightly interconnected that the formation of the final product is driven by a precise not interfering sequence of B 2-B 2 (or A 2-A 2) mechanisms.
View Article and Find Full Text PDFComparison of Eco-friendly Ti-M Bimetallic Coordination Catalysts and Commercial Monometallic Sb- or Ti-Based Catalysts for the Synthesis of Poly(ethylene--isosorbide terephthalate).
ACS Omega
June 2023
School of Materials and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, P. R. China.
Sustainable development greatly benefits from the effective synthesis of bio-based copolymers that are environmentally friendly. To enhance the polymerization reactivity for the production of poly(ethylene--isosorbide terephthalate) (PEIT), five highly active Ti-M (M = Mg, Zn, Al, Fe, and Cu) bimetallic coordination catalysts were designed. The catalytic activity of Ti-M bimetallic coordination catalysts and single Sb- or Ti-based catalysts was compared, and the effects of catalysts with a different type of coordination metal (Mg, Zn, Al, Fe, and Cu) on the thermodynamic and crystallization properties of copolyesters were explored.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!