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Zinc Combined with Metformin Corrects Zinc Homeostasis and Improves Steroid Synthesis and Semen Quality in Male Type 2 Diabetic Mice by Activating PI3K/AKT/mTOR Pathway.
Biol Trace Elem Res
January 2025
Hebei Key Laboratory of Reproductive Medicine, Hebei Reproductive Health Hospital, Shijiazhuang 050071, Hebei, China.
Male infertility is a common complication of diabetes. Diabetes leads to the decrease of zinc (Zn) content, which is a necessary trace element to maintain the normal structure and function of reproductive organs and spermatogenesis. The purpose of this study was to investigate the effect of metformin combined with zinc on testis and sperm in diabetic mice.
View Article and Find Full Text PDFUltrafast Dissociation Dynamics of the Sensitive Explosive Ethylene Glycol Dinitrate.
J Phys Chem Lett
January 2025
Department of Chemistry, Virginia Commonwealth University, Richmond, Virginia 23284, United States.
Ethylene glycol dinitrate (EGDN) is a nitrate ester explosive widely used in military ordnance and missile systems. This study investigates the decomposition dynamics of the EGDN cation using a comprehensive approach that combines femtosecond time-resolved mass spectrometry (FTRMS) experiments with electronic structure and molecular dynamics computations. We identify three distinct dissociation time scales for the metastable EGDN cation of approximately 40-60 fs, 340-450 fs, and >2 ps.
View Article and Find Full Text PDFInteraction of STIL with FOXM1 regulates SF3A3 transcription in the hepatocellular carcinoma development.
Cell Div
January 2025
Second Department of General Surgery, the First Hospital of Qiqihar, No. 700, Pukui avenue, Long sha District, Qiqihar, Heilongjiang, 161000, P. R. China.
Background: Dysregulation of SF3A3 has been related to the development of many cancers. Here, we investigated the functional role of SF3A3 in hepatocellular carcinoma (HCC).
Methods: SF3A3 expression in HCC tissues and cell lines was examined using RT-qPCR.
Harnessing the synergy of Urochloa brizantha and Amazonian Dark Earth microbiomes for enhanced pasture recovery.
BMC Microbiol
January 2025
Center for Nuclear Energy in Agriculture, University of São Paulo, Piracicaba, SP, Brazil.
Amazonian Dark Earths (ADEs) are fertile soils from the Amazon rainforest that harbor microorganisms with biotechnological potential. This study aimed to investigate the individual and potential synergistic effects of a 2% portion of ADEs and Urochloa brizantha cv. Marandu roots (Brazil's most common grass species used for pastures) on soil prokaryotic communities and overall soil attributes in degraded soil.
View Article and Find Full Text PDFYOLOSeg with applications to wafer die particle defect segmentation.
Sci Rep
January 2025
Department of Industrial Engineering and Management, Ming Chi University of Technology, New Taipei City, 243, Taiwan.
This study develops the you only look once segmentation (YOLOSeg), an end-to-end instance segmentation model, with applications to segment small particle defects embedded on a wafer die. YOLOSeg uses YOLOv5s as the basis and extends a UNet-like structure to form the segmentation head. YOLOSeg can predict not only bounding boxes of particle defects but also the corresponding bounding polygons.
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