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Current androgen receptor antagonists under investigation for resistant prostate cancer: progress and challenges.
Expert Rev Anticancer Ther
March 2025
Medical Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Introduction: Prostate cancer represents a significant oncological challenge, with its natural history predominantly driven by androgen receptor (AR) signaling. The pivotal role of this pathway underscores the rationale for targeting AR activity in therapeutic strategies. However, the development of resistance mechanisms has highlighted the need for advanced therapies to address the complexity of the castration-resistant status.
View Article and Find Full Text PDFObjective: To examine the accuracy of the Australia and New Zealand Dialysis and Transplant Registry (ANZDATA), the population-based clinical quality registry for people with kidney failure, in identifying Aboriginal and/or Torres Strait Islander people.
Design: Population-based cohort study of reporting accuracy.
Setting: New South Wales, 2006-2020.
Normothermic Machine Perfusion Improves Outcomes for Donation After Cardiac Death Allografts With Extended Donor Warm Ischemia Time.
Clin Transplant
March 2025
Department of Surgery, Division of Transplant Surgery, Mayo Clinic Arizona, Scottsdale, Arizona, USA.
Introduction: Donation after circulatory death (DCD) allografts are underutilized in liver transplantation (LT) due to increased risk of complications. These risks stem from ischemic injury sustained during the total donor warm ischemia time (tDWIT), historically limited to 30 min. Normothermic machine perfusion (NMP) can mitigate these risks and facilitate LT of DCD grafts with extended tDWIT.
View Article and Find Full Text PDFCongenital adrenal hyperplasia (CAH) is a defect in one of the enzymes or transport proteins involved in the synthesis of cortisol in the adrenal cortex. Virile form of CAH characterized by cortisol deficiency and hyperandrogenism. Klinefelter syndrome is one of the most frequent chromosomal diseases leading to the development of primary hypogonadism.
View Article and Find Full Text PDFPseudoaneurysm-Induced Pain Following Ankle Arthroscopy: A Case Report and Literature Review.
Am J Case Rep
March 2025
Department of Orthopedic Surgery, Ajou University School of Medicine, Suwon, South Korea.
BACKGROUND Arthroscopic surgery is esteemed for its arthroscopic lateral ligament repair to treating ankle ligament injuries, characterized by a low complication rate. Nevertheless, rare complications such as pseudoaneurysms require careful monitoring and a strategic approach to management during the postoperative follow-up period. This case report details a 42-year-old man with chronic instability in his left ankle.
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